The Lifespan Trajectories of Brain Activities Related to Cognitive Control.

Autor:	Li Z; Institute of Brain Science and Department of Physiology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.; Zhejiang Philosophy and Social Science Laboratory for Research in Early Development and Childcare, Hangzhou Normal University, Hangzhou, China.; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China.; Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China., Petersen IT; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA., Wang L; Centre for Cognition and Brain disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, China.; Institute of Psychological Science, Hangzhou Normal University, Hangzhou, Zhejiang Province, China.; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China., Radua J; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, University of Barcelona, Barcelona, Spain.; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden., Yang GC; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.; Cognitive Control Collaborative, University of Iowa, Iowa City, IA, USA.; Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China., Liu X; Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 16. Date of Electronic Publication: 2024 Sep 16.
DOI:	10.1101/2023.08.20.554018
Abstrakt:	Cognitive control plays a pivotal role in guiding human goal-directed behavior. While existing studies have documented an inverted U-shaped trajectory of cognitive control both behaviorally and anatomically, little is known about the corresponding changes in functional brain activation with age. To bridge this gap, we conducted a comprehensive meta-analysis of 129 neuroimaging studies using conflict tasks, encompassing 3,388 participants aged from 5 to 85 years old. We have three major findings: 1) The inverted U-shaped trajectory is the predominant pattern; 2) Cognitive control-related brain regions exhibit heterogeneous lifespan trajectories: the frontoparietal control network follows inverted U-shaped trajectories, peaking between 24 and 40 years, while the dorsal attention network demonstrates no clear trajectories; 3) Both the youth and the elderly show weaker brain activities and greater left laterality than young to middle-aged adults. These results reveal the lifespan trajectories of cognitive control, highlighting heterogeneous fluctuations in brain networks with age. Competing Interests: Competing Interests Statement The authors declare no competing interests.
Databáze:	MEDLINE
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