| Autor: |
Benvenuto M; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy.; Departmental Faculty of Medicine and Surgery, Saint Camillus International University of Health and Medical Sciences, Rome, Italy., Nardozi D; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy., Palumbo C; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy., Focaccetti C; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy., Carrano R; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy., Angiolini V; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy., Cifaldi L; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy., Lucarini V; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy., Mancini P; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy., Kërpi B; Department of Biomedicine, Catholic University, 'Our Lady of Good Counsel', Tirana, Albania.; Department of Chemical Sciences and Technologies, University of Rome 'Tor Vergata', Rome, Italy., Currenti W; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy., Bei R; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy.; Catholic University, 'Our Lady of Good Counsel', Tirana, Albania., Masuelli L; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. |
| Abstrakt: |
Several attempts have been made to develop targeted therapies for malignant mesothelioma (MM), an aggressive tumour with a poor prognosis. In this study we evaluated whether Curcumin (CUR) potentiated the antitumor activity of the ErbB receptors inhibitor Afatinib (AFA) on MM, employing cell lines cultured in vitro and mice bearing intraperitoneally transplanted, syngeneic MM cells. The rationale behind this hypothesis was that CUR could counteract mechanisms of acquired resistance to AFA. We analysed CUR and AFA effects on MM cell growth, cell cycle, autophagy, and on the modulation of tumour-supporting signalling pathways.This study demonstrated that, as compared to the individual compounds, the combination of AFA + CUR had a stronger effect on MM progression which can be ascribed either to increased tumour cell growth inhibition or to an enhanced pro-apoptotic effect. These results warrant future studies aimed at further exploring the therapeutic potential of AFA + CUR-based combination regimens for MM treatment. |
