Surgical Management of Full-Thickness Macular Holes in Macular Telangiectasia Type 2: A Global Multicenter Study.

Autor:	Park JG; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan., Adrean SD; Retina Consultants of Orange County, Fullerton, California., Begaj T; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan., Capone A Jr; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan., Charles S; University of Tennessee and Charles Retina Institute, Memphis, Tennessee., Chen SN; Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan., Chou HD; College of Medicine, Chang Gung University, and Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan, Taiwan., Cohen MN; Wills Eye Hospital, Mid Atlantic Retina, and Thomas Jefferson University, Philadelphia, Pennsylvania., Corona ST; Retina Consultants of Texas, and Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas., Faia LJ; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan., Garg SJ; Wills Eye Hospital, Mid Atlantic Retina, and Thomas Jefferson University, Philadelphia, Pennsylvania., Garretson BR; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan., Gregori NZ; Bascom Palmer Eye Institute, Miami, Florida., Haller JA; Wills Eye Hospital, Mid Atlantic Retina, and Thomas Jefferson University, Philadelphia, Pennsylvania., Houghton OM; Mayo Clinic Arizona, Scottsdale, Arizona., Hsu J; Wills Eye Hospital, Mid Atlantic Retina, and Thomas Jefferson University, Philadelphia, Pennsylvania., Jo J; Department of Ophthalmology, Asan Medical Center University of Ulsan College of Medicine, Seoul, Republic of Korea., Kaiser RS; Wills Eye Hospital, Mid Atlantic Retina, and Thomas Jefferson University, Philadelphia, Pennsylvania., Lai CC; College of Medicine, Chang Gung University, Taoyuan, Taiwan, and Chang Gung Memorial Hospital, Keelung, Taiwan., Mahgoub MM; Ain-Shams University, Cairo, Egypt., Mansoor M; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, and Iowa Institute for Vision Research, University of Iowa, Iowa City, Iowa., Matoba R; Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Morizane Y; Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Nehemy MB; Department of Ophthalmology, Federal University of Minas Gerais, Belo Horizonte, Brazil., Raphaelian PV; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan., Regillo CD; Wills Eye Hospital, Mid Atlantic Retina, and Thomas Jefferson University, Philadelphia, Pennsylvania., Ruby AJ; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan., Runner MM; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan., Sneed SR; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan., Sohn EH; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, and Iowa Institute for Vision Research, University of Iowa, Iowa City, Iowa., Spirn MJ; Wills Eye Hospital, Mid Atlantic Retina, and Thomas Jefferson University, Philadelphia, Pennsylvania., Vander JF; Wills Eye Hospital, Mid Atlantic Retina, and Thomas Jefferson University, Philadelphia, Pennsylvania., Wakabayashi T; Wills Eye Hospital, Mid Atlantic Retina, and Thomas Jefferson University, Philadelphia, Pennsylvania., Wolfe JD; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan., Wykoff CC; Retina Consultants of Texas, and Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas., Yonekawa Y; Wills Eye Hospital, Mid Atlantic Retina, and Thomas Jefferson University, Philadelphia, Pennsylvania., Yoon YH; Department of Ophthalmology, Asan Medical Center University of Ulsan College of Medicine, Seoul, Republic of Korea., Mahmoud TH; Associated Retinal Consultants, and Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan. Electronic address: thmahmoud@yahoo.com.
Jazyk:	angličtina
Zdroj:	Ophthalmology [Ophthalmology] 2024 Jan; Vol. 131 (1), pp. 66-77. Date of Electronic Publication: 2023 Sep 03.
DOI:	10.1016/j.ophtha.2023.08.025
Abstrakt:	Purpose: To report on macular hole repair in macular telangiectasia type 2 (MacTel2). Design: Global, multicenter, retrospective case series. Participants: Patients undergoing surgery for MacTel2-associated full-thickness macular hole (MTMH). Methods: Standardized data collection sheet distributed to all surgeons. Main Outcome Measures: Anatomic closure and visual outcomes of MTMH. Results: Sixty-three surgeries in 47 patients with MTMH were included from 30 surgeons. Mean age was 68.1 years, with 62% female, 72% White, 21% East or South Asian, 2% African American, and 2% Hispanic or Latino. Procedures included 34 internal limiting membrane (ILM) peeling alone, 22 ILM flaps, 5 autologous retinal transplantations (ARTs), 1 retinotomy, and 1 subretinal bleb. For ILM peeling, preoperative visual acuity (VA) was 0.667 ± 0.423 logarithm of the minimum angle of resolution (logMAR). Minimum hole diameter (MHD) was 305.5 ± 159.4 μm (range, 34-573 μm). Sixteen of 34 ILM peels (47%) resulted in MTMH closure. At postoperative month 6, VA was stable at 0.602 ± 0.516 logMAR (P = 0.65). VA improved by at least 2 lines in 43% and at least 4 lines in 24%. For ILM flaps, preoperative VA was 0.878 ± 0.552 logMAR. MHD was 440.8 ± 175.5 μm (range, 97-697 μm), which was significantly larger than for ILM peels (P < 0.01). Twenty of 22 ILM flaps (90%) resulted in MTMH closure, which was significantly higher than for ILM peels (P < 0.01). At postoperative month 6, VA improved to 0.555 ± 0.405 logMAR (P < 0.05). VA improved by at least 2 lines in 56% and at least 4 lines in 28%. For ARTs, preoperative VA was 1.460 ± 0.391 logMAR. MHD was 390.2 ± 203.7 μm (range, 132-687 μm). All 5 ARTs (100%) resulted in MTMH closure. At postoperative month 6, VA was stable at 1.000 ± 0.246 logMAR (P = 0.08). Visual acuity improved at least 2 lines in 25%. Conclusions: Surgical closure of macular holes improved VA in 57% of MTMHs. Internal limiting membrane flaps achieved better anatomic and functional outcomes than ILM peeling alone. Autologous retinal transplantation may be an option for refractory MTMHs. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. (Copyright © 2023 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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