Longitudinal Child Growth Patterns in Twins and Singletons in the Upstate KIDS Cohort.

Autor: Gleason JL; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD., Yeung EH; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD., Sundaram R; Biostatistics and Bioinformatics Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD., Putnick DL; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD., Mendola P; Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY., Bell EM; Departments of Environmental Health Sciences and Epidemiology and Biostatistics University at Albany, School of Public Health, Rensselaer, NY., Polinski KJ; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD., Robinson SL; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD., Grantz KL; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD. Electronic address: katherine.grantz@nih.gov.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2023 Dec; Vol. 263, pp. 113720. Date of Electronic Publication: 2023 Sep 01.
DOI: 10.1016/j.jpeds.2023.113720
Abstrakt: Objectives: To investigate childhood growth patterns in twins and to determine whether they show the same signs of excess growth as singletons born small-for-gestational age (SGA), which may confer future cardiometabolic risk.
Study Design: In the Upstate KIDS cohort of infants delivered from 2008 through 2010, we compared height, weight, and body mass index (BMI) z-scores at 0-3 and 7-9 years of age, as well as risk of rapid weight gain (RWG) in infancy and overweight/obesity beginning at 2 years, among appropriate-for-gestational age (AGA) twins (n = 1121), AGA singletons (n = 2684), and two groups of SGA twins: uncertain SGA twins (<10th percentile for birthweight by a singleton reference but >10th% by a population-based twin birthweight reference; n = 319) and true SGA twins (<10th% by a population-based twin reference; n = 144).
Results: Compared with AGA twins, both SGA twin groups had lower weight and BMI z-scores at both time points. By 7-9 years, both groups caught up in height with AGA twins. Compared with AGA singletons, z-score differences decreased between 0-3 and 7-9 years for uncertain SGA and true SGA twins, though true SGA twins had the lowest z-scores for all measures. During infancy, twins were more likely to display RWG compared with AGA singletons (RR = 2.06 to 2.67), which may reflect normal catch-up growth, as no twin group had higher prevalence of overweight/obesity at either time point.
Conclusions: Though twins had lower height, weight, and BMI z-scores at birth and into toddlerhood, differences were reduced by 7-9 years, with no evidence of pathological growth and no group of twins showing elevated risk of overweight/obesity.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to disclose. Funding: This study was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (contracts #HHSN275201200005 C, #HHSN267200700019 C, #HHSN275201400013 C, #HHSN275201300026I/27500004). JLG, EHY, RS, DLP, and KLG have contributed to this work as part of their official duties as employees of the United States Federal Government. Role of Funder: The funder/sponsor did not participate in the work, to include study design, collection, analysis, or interpretation of data, the writing of the manuscript, or the decision to submit the manuscript for publication. Prior Presentation of Findings: Findings from this work have been partially presented at the Annual Meeting of the Society for Epidemiologic Research in June, 2022 and at the Annual Meeting of the Society for Maternal Fetal Medicine in February, 2023.
(Published by Elsevier Inc.)
Databáze: MEDLINE
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