A journey with psychedelic mushrooms: From historical relevance to biology, cultivation, medicinal uses, biotechnology, and beyond.

Autor: Pepe M; Department of Plant Agriculture, University of Guelph, Ontario N1G 2W1, Guelph, Canada., Hesami M; Department of Plant Agriculture, University of Guelph, Ontario N1G 2W1, Guelph, Canada., de la Cerda KA; School of Environmental Sciences, University of Guelph, Ontario N1G 2W1, Guelph, Canada., Perreault ML; Departments of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Hsiang T; School of Environmental Sciences, University of Guelph, Ontario N1G 2W1, Guelph, Canada., Jones AMP; Department of Plant Agriculture, University of Guelph, Ontario N1G 2W1, Guelph, Canada. Electronic address: amjones@uoguelph.ca.
Jazyk: angličtina
Zdroj: Biotechnology advances [Biotechnol Adv] 2023 Dec; Vol. 69, pp. 108247. Date of Electronic Publication: 2023 Sep 01.
DOI: 10.1016/j.biotechadv.2023.108247
Abstrakt: Psychedelic mushrooms containing psilocybin and related tryptamines have long been used for ethnomycological purposes, but emerging evidence points to the potential therapeutic value of these mushrooms to address modern neurological, psychiatric health, and related disorders. As a result, psilocybin containing mushrooms represent a re-emerging frontier for mycological, biochemical, neuroscience, and pharmacology research. This work presents crucial information related to traditional use of psychedelic mushrooms, as well as research trends and knowledge gaps related to their diversity and distribution, technologies for quantification of tryptamines and other tryptophan-derived metabolites, as well as biosynthetic mechanisms for their production within mushrooms. In addition, we explore the current state of knowledge for how psilocybin and related tryptamines are metabolized in humans and their pharmacological effects, including beneficial and hazardous human health implications. Finally, we describe opportunities and challenges for investigating the production of psychedelic mushrooms and metabolic engineering approaches to alter secondary metabolite profiles using biotechnology integrated with machine learning. Ultimately, this critical review of all aspects related to psychedelic mushrooms represents a roadmap for future research efforts that will pave the way to new applications and refined protocols.
Competing Interests: Declaration of Competing Interest The authors declare that we have no conflict of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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