Aggregation-induced enhancement of pyrene-based metal-organic framework as a new electrochemiluminescence emitter for ultrasensitive detection of sulfadimethoxine.

Autor: Liu J; Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China., Mu Z; Research Center for Pharmacodynamic Evaluation Engineering Technology of Chongqing, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China., Zhou J; Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China., Qing M; Research Center for Pharmacodynamic Evaluation Engineering Technology of Chongqing, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China. Electronic address: mindaqing@cqmu.edu.cn., Bai L; Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China. Electronic address: bailj1018@cqmu.edu.cn.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2024 Jan 30; Vol. 432, pp. 137270. Date of Electronic Publication: 2023 Aug 25.
DOI: 10.1016/j.foodchem.2023.137270
Abstrakt: In this study, a signal-on electrochemiluminescence (ECL) aptasensor for ultrasensitive detection of sulfadimethoxine (SDM) was constructed based on a competitive aptamer strategy. Specifically, cerium-metal-organic framework (Ce-MOF) with large specific surface area and excellent electrical conductivity was combined with gold nanoparticles (AuNPs) to form a substrate, followed by the immobilisation of double-stranded DNA (dsDNA) via AuN bonds. In the presence of SDM, the aptamer tended to form an aptamer-SDM complex, which caused dsDNA to dissociate. After release of the aptamer, the capture probe (CP) combined with the tracer label to enhance the ECL signal. As expected, the prepared sensor displayed an ideal linear response range from 10.0 fg mL -1 to 100 ng mL -1 with a limit of detection (LOD) of 1.28 fg mL -1 and successfully detected SDM in milk and quality control samples.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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