A cognitive marker for Alzheimer disease pathology in primary progressive aphasia? A validation study in the clinical setting.

Autor: Isella V; School of Medicine and Surgery, University of Milano - Bicocca, Monza (MB), Italy. Electronic address: valeria.isella@unimib.it., Licciardo D; School of Medicine and Surgery, University of Milano - Bicocca, Monza (MB), Italy; Neurology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza (MB), Italy., Rebecchi G; School of Medicine and Surgery, University of Milano - Bicocca, Monza (MB), Italy., Ferri F; Neurology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza (MB), Italy., Crivellaro C; Nuclear Medicine Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza (MB), Italy., Appollonio I; School of Medicine and Surgery, University of Milano - Bicocca, Monza (MB), Italy; Neurology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza (MB), Italy., Ferrarese C; School of Medicine and Surgery, University of Milano - Bicocca, Monza (MB), Italy; Neurology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza (MB), Italy.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2023 Nov; Vol. 131, pp. 153-155. Date of Electronic Publication: 2023 Jul 16.
DOI: 10.1016/j.neurobiolaging.2023.07.003
Abstrakt: We validated in the clinical setting a putative clinical marker for a biological diagnosis of primary progressive aphasia (PPA) due to amyloid previously identified in an autopsy cohort and including impaired (score ≤4) digit span (DS) as index of phonological loop dysfunction and broadened criteria for logopenic PPA. In 29 PPA patients with an amyloid-positive (A+) biomarker and 28 PPA patients with an amyloid-negative (A-) biomarker, Receiver Operating Characteristics (ROC) curve analysis showed moderate specificity (71%) but insufficient sensitivity (41%) for the proposed marker. Specificity was particularly poor (58%) for the discrimination between A+ PPA and the A- subgroup with nonfluent PPA. DS may be compromised in both logopenic and nonfluent PPA, whose loci of neurodegeneration lie at the 2 ends of the left fronto-parieto-temporal system that underpins phonology. An Statistical Parametric Mapping (SPM) correlation analysis between DS score and metabolism on brain 18-fluoro-deoxy-glucose positron emission tomography also showed a major contribution of the left frontal cortex to impaired span.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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