5-Hydroxytryptophan toxicity successfully treated by haemodialysis in a dog.

Autor: Arbona DV; Veterinary Specialty Hospital by Ethos Veterinary Health, San Diego, California, USA., Cowgill LD; Advanced Extracorporeal and Urinary Disease Service, UC Veterinary Medical Center-San Diego, San Diego, California, USA., Press S; Veterinary Specialty Hospital by Ethos Veterinary Health, San Diego, California, USA., Dufayet C; Advanced Extracorporeal and Urinary Disease Service, UC Veterinary Medical Center-San Diego, San Diego, California, USA., Istvan S; Veterinary Specialty Hospital by Ethos Veterinary Health, San Diego, California, USA.
Jazyk: angličtina
Zdroj: Veterinary medicine and science [Vet Med Sci] 2023 Nov; Vol. 9 (6), pp. 2438-2442. Date of Electronic Publication: 2023 Sep 02.
DOI: 10.1002/vms3.1253
Abstrakt: Objective: To describe a case of 5-hydroxytryptophan (5-HTP) toxicity successfully treated with haemodialysis in a dog.
Case Summary: A 3-year-old, male neutered Labrador Retriever, weighing 28.2 kg, presented to the emergency department approximately 4-5 h after ingesting a human supplement containing 200 mg of 5-HTP. The amount of 5-HTP ingested was estimated between 980 and 1988 mg (35-71 mg/kg). At presentation, the dog demonstrated progressive neurologic abnormalities consistent with serotonin syndrome, including altered mentation and ataxia. Due to the magnitude of the ingested dose and progression of clinical signs, extracorporeal blood purification with intermittent haemodialysis was chosen to expedite clearance of 5-HTP. High-efficiency haemodialysis was initiated, and the dog showed continued clinical improvement throughout the 5-h treatment. Clinical signs resolved completely within 12 h. Sequential blood and urine samples were obtained to document levels of both 5-HTP and serotonin. The dog was discharged 24 h after presentation with complete resolution of clinical signs.
New or Unique Information: This is the first report documenting the serial changes in 5-HTP concentrations during treatment with haemodialysis.
(© 2023 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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