Pregnancy, fertile life factors, and associated clinical course in PRKN early-onset Parkinson's disease.

Autor: Bovenzi R; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 00133, Rome, Italy., Conti M; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 00133, Rome, Italy., Degoli GR; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 00133, Rome, Italy., Cerroni R; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 00133, Rome, Italy., Artusi CA; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy., Pierantozzi M; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 00133, Rome, Italy., Stefani A; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 00133, Rome, Italy.; UOSD Parkinson Centre, Tor Vergata University Hospital, Rome, Italy., Mercuri NB; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 00133, Rome, Italy., Schirinzi T; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 00133, Rome, Italy. t.schirinzi@yahoo.com.
Jazyk: angličtina
Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2024 Feb; Vol. 45 (2), pp. 591-599. Date of Electronic Publication: 2023 Sep 02.
DOI: 10.1007/s10072-023-07029-8
Abstrakt: Introduction: As the most common cause of autosomal recessive early onset Parkinson's disease (EOPD), parkin type Parkinson's disease (PRKN-PD) may affect female patients in childbearing age. Accordingly, issues related to fertility must be adequately addressed. Here, we landscaped fertile life factors and pregnancy course of a PRKN-PD cohort, including both novel cases directly observed at our center and published ones.
Methods: Six patients with confirmed PRKN-PD were examined by a structured interview on reproductive factors and associated modifications of PD disturbances, including one case followed up throughout pregnancy which was described in greater detail. Six studies reporting fertile life factors of nine PRKN-PD patients were reviewed collecting homogeneous data on fertile life and pregnancy course.
Results: PRKN-PD female patients experienced motor fluctuations with the menstrual cycle, pregnancy, and puerperium, which suggests a role for sex hormones in PD clinical burden. In some cases, abortion and miscarriages occurred during the organogenesis phase in patients receiving oral antiparkinsonian therapy; however, levodopa/benserazide monotherapy resulted to be the safest choice in pregnancy.
Conclusion: Collectively these data disclose the importance of pre-conception counseling in childbearing age PRKN-PD patients and EOPD in general.
(© 2023. The Author(s).)
Databáze: MEDLINE
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