Familial Mediterranean fever: perspective on female fertility and disease course in pregnancy from a multicenter nationwide network.

Autor: Yurdakul FG; Department of Physical Medicine and Rehabilitation, Ankara City Hospital, University of Health Sciences, Ankara, Turkey. fatmagulonder@gmail.com., Bodur H; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ministry of Health Ankara City Hospital, Yıldırım Beyazıt University, Ankara, Turkey., Çay HF; Rheumatology Clinic, Department of Physical Medicine and Rehabilitation, Antalya Training and Research Hospital, Antalya, Turkey., Uçar Ü; Rheumatology Clinic, Department of Physical Medicine and Rehabilitation, Antalya Training and Research Hospital, Antalya, Turkey., Keskin Y; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey., Sargın B; Department of Rheumatology, Aydın State Hospital, Aydin, Turkey., Gürer G; Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey., Yurdakul OV; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey., Çalış M; Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Erciyes University Faculty of Medicine, Kayseri, Turkey., Deveci H; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey., Aydın Y; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Sakarya University, Sakarya, Turkey., Hizmetli S; Department of Physical Medicine and Rehabilitation Rheumatology Clinic, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey., Çevik R; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Dicle University, Diyarbakir, Turkey., Karahan AY; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Uşak University, Uşak, Turkey., Ataman Ş; Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ankara University, Ankara, Turkey., Duruöz MT; Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Marmara University, Istanbul, Turkey., Ecesoy H; Department of Physical Medicine and Rehabilitation Rheumatology Clinic, Faculty of Medicine, Karamanoğlu Mehmetbey University, Karaman, Turkey., Günendi Z; Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Gazi University, Ankara, Turkey., Toprak M; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Turkey., Şen N; Rheumatology Clinic, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Istanbul, Turkey., Altıntaş D; Division of Rheumatology, Fatsa State Hospital, Fatsa/Ordu, Turkey., Cengiz AK; Department of Physical Medicine and Rehabilitation, 19 Mayıs University Faculty of Medicine, Samsun, Turkey., Çağlayan G; Department of Physical Medicine and Rehabilitation Rheumatology Clinic, Cumhuriyet University Faculty of Medicine, Sivas, Turkey., Demir AN; Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Akdeniz University Faculty of Medicine, Antalya, Turkey., Kaplan H; Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Erciyes University Faculty of Medicine, Kayseri, Turkey., Ketenci S; Department of Physical Medicine and Rehabilitation, 19 Mayıs University Faculty of Medicine, Samsun, Turkey., Alkan Melikoğlu M; Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Atatürk University, Erzurum, Turkey., Nayimoğlu M; Department of Physical Medicine and Rehabilitation Höxter, Asklepios Weserbergland Klinik, Höxter, Germany., Nas K; Department of Physical Medicine and Rehabilitation, Division of Rheumatology and Immunology, Sakarya University Faculty of Medicine, Sakarya, Turkey., Sarıfakıoğlu B; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey., Sezer İ; Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Jazyk: angličtina
Zdroj: Rheumatology international [Rheumatol Int] 2024 Oct; Vol. 44 (10), pp. 2117-2127. Date of Electronic Publication: 2023 Sep 02.
DOI: 10.1007/s00296-023-05436-w
Abstrakt: The aim of this study was to analyze the pregnancy process, especially the Familial Mediterranean fever (FMF) disease course and attack types during pregnancy, and to examine the relationship between disease-related factors and female infertility in FMF patients. The study, which was planned in a multicenter national network, included 643 female patients. 435 female patients who had regular sexual intercourse were questioned in terms of infertility. Pregnancy and delivery history, FMF disease severity and course during pregnancy were evaluated. The relationship between demographic and clinical findings, disease severity, genetic analysis results and infertility was investigated. 401 patients had at least 1 pregnancy and 34 patients were diagnosed with infertility. 154 patients had an attack during pregnancy. 61.6% of them reported that attacks during pregnancy were similar to those when they were not pregnant. The most common attack symptoms were fever, fatigue and abdominal pain-peritonitis (96%, 87%, and 83%, respectively) in the pregnancy period. The disease-onset age, disease activity score, gene mutation analyses, and regular colchicine use (> 90%) were similar between the fertile and infertile groups, while the frequency of previous appendectomy and alcohol consumption rates were higher in individuals with infertility. Our results indicated no significant change in the frequency and severity of attacks during pregnancy. The low rate of infertility (7.8%) in our patients was noted. It has been suggested that the risk of FMF-related infertility may not be as high as thought in patients who are followed up regularly and received colchicine.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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