Outcomes up to age 36 months after congenital Zika virus infection-U.S. states.

Autor:	Neelam V; Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA. pju4@cdc.gov., Woodworth KR; Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA., Chang DJ; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA., Roth NM; Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA., Reynolds MR; Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA., Akosa A; Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA., Carr CP; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA., Anderson KN; Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA., Mulkey SB; Children's National Hospital, Washington, D. C., USA.; The George Washington University School of Medicine and Health Sciences, Washington, D. C., USA., DeBiasi RL; Children's National Hospital, Washington, D. C., USA.; The George Washington University School of Medicine and Health Sciences, Washington, D. C., USA., Biddle C; Children's National Hospital, Washington, D. C., USA.; The George Washington University School of Medicine and Health Sciences, Washington, D. C., USA., Lee EH; New York City Department of Health & Mental Hygiene, New York City, NY, USA., Elmore AL; Florida Department of Health, Tampa, FL, USA., Scotland SJ; Massachusetts Department of Public Health, Boston, MA, USA., Sowunmi S; California Department of Public Health, Sacramento, CA, USA., Longcore ND; New York State Department of Health, Albany, NY, USA., Ahmed M; New Jersey Department of Health, Trenton, NJ, USA., Langlois PH; Texas Department of State Health Services, Austin, TX, USA., Khuwaja S; Houston Health Department, Houston, TX, USA., Browne SE; Virginia Department of Health, Richmond, VA, USA., Lind L; Pennsylvania Department of Health, Pittsburgh, PA, USA., Shim K; Dallas County Health and Human Services, Dallas, TX, USA., Gosciminski M; Rhode Island Department of Health, Providence, RI, USA., Blumenfeld R; Philadelphia Department of Public Health, Philadelphia, PA, USA., Khuntia S; District of Columbia Department of Health, Washington, D. C, USA., Halai UA; Los Angeles County Department of Public Health, Los Angeles, CA, USA., Locklear A; North Carolina Department of Health and Human Services, Chapel Hill, NC, USA., Chan M; Washington State Department of Health, Seattle, WA, USA., Willabus T; Georgia Department of Public Health, Atlanta, GA, USA., Tonzel J; Louisiana Department of Health, New Orleans, LA, USA., Marzec NS; Colorado Department of Public Health and Environment, Denver, CO, USA., Barreto NA; Hawaii Department of Health, Honolulu, HI, USA., Sanchez C; Hidalgo County Health & Human Services Department, Hidalgo, TX, USA., Fornoff J; Illinois Department of Public Health, Springfield, IL, USA., Hale S; Ohio Department of Health, Columbus, OH, USA., Nance A; Utah Department of Health and Human Services, Salt Lake City, UT, USA., Iguchi L; Oregon Health Authority, Salem, OR, USA., Adibhatla SN; Wisconsin Department of Health Services, Madison, WI, USA., Potts E; Indiana Department of Health, Indianapolis, IN, USA., Schiffman E; Minnesota Department of Health, Minneapolis, MN, USA., Raman D; Southern Nevada Health District, Las Vegas, NV, USA., McDonald MF; Tennessee Department of Health, Nashville, TN, USA., Stricklin B; Arkansas Department of Health, Little Rock, AR, USA., Ludwig E; Nebraska Department of Health and Human Services, Lincoln, NE, USA., Denson L; Oklahoma State Department of Health, Oklahoma City, OK, USA., Contreras D; Arizona Department of Health Services, Tempe, AZ, USA., Romitti PA; University of Iowa College of Public Health, Iowa City, IA, USA., Ferrell E; Kentucky Department for Public Health, Georgetown, KY, USA., Marx M; South Dakota Department of Health, Pierre, SD, USA., Signs K; Michigan Department of Health and Human Services, Lansing, MI, USA., Cook A; Kansas Department of Health and Environment, Topeka, KS, USA., Leedom VO; South Carolina Department of Health and Environmental Control, Florence, SC, USA., Beauregard S; New Hampshire Department of Health and Human Services, Concord, NH, USA., Orantes LC; Vermont Department of Health, Burlington, VT, USA., Cronquist L; North Dakota Department of Health, Bismarck, ND, USA., Roush L; West Virginia Bureau for Public Health, Charleston, WV, USA., Godfred-Cato S; Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA., Gilboa SM; Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA., Meaney-Delman D; Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA., Honein MA; Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA., Moore CA; Goldbelt Professional Services, LLC, Chesapeake, VA, USA., Tong VT; Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jazyk:	angličtina
Zdroj:	Pediatric research [Pediatr Res] 2024 Jan; Vol. 95 (2), pp. 558-565. Date of Electronic Publication: 2023 Sep 01.
DOI:	10.1038/s41390-023-02787-9
Abstrakt:	Background: To characterize neurodevelopmental abnormalities in children up to 36 months of age with congenital Zika virus exposure. Methods: From the U.S. Zika Pregnancy and Infant Registry, a national surveillance system to monitor pregnancies with laboratory evidence of Zika virus infection, pregnancy outcomes and presence of Zika associated birth defects (ZBD) were reported among infants with available information. Neurologic sequelae and developmental delay were reported among children with ≥1 follow-up exam after 14 days of age or with ≥1 visit with development reported, respectively. Results: Among 2248 infants, 10.1% were born preterm, and 10.5% were small-for-gestational age. Overall, 122 (5.4%) had any ZBD; 91.8% of infants had brain abnormalities or microcephaly, 23.0% had eye abnormalities, and 14.8% had both. Of 1881 children ≥1 follow-up exam reported, neurologic sequelae were more common among children with ZBD (44.6%) vs. without ZBD (1.5%). Of children with ≥1 visit with development reported, 46.8% (51/109) of children with ZBD and 7.4% (129/1739) of children without ZBD had confirmed or possible developmental delay. Conclusion: Understanding the prevalence of developmental delays and healthcare needs of children with congenital Zika virus exposure can inform health systems and planning to ensure services are available for affected families. Impact: We characterize pregnancy and infant outcomes and describe neurodevelopmental abnormalities up to 36 months of age by presence of Zika associated birth defects (ZBD). Neurologic sequelae and developmental delays were common among children with ZBD. Children with ZBD had increased frequency of neurologic sequelae and developmental delay compared to children without ZBD. Longitudinal follow-up of infants with Zika virus exposure in utero is important to characterize neurodevelopmental delay not apparent in early infancy, but logistically challenging in surveillance models. (© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze:	MEDLINE
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