Pathogenic Leptospira are widespread in the urban wildlife of southern California.

Autor: Helman SK; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA. sarahkh@ucla.edu.; Institute of the Environment and Sustainability, University of California, Los Angeles, CA, USA. sarahkh@ucla.edu., Tokuyama AFN; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA., Mummah RO; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA., Stone NE; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA., Gamble MW; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA.; Institute of the Environment and Sustainability, University of California, Los Angeles, CA, USA., Snedden CE; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA., Borremans B; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA.; Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium.; Wildlife Health Ecology Research Organization, San Diego, CA, USA., Gomez ACR; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA., Cox C; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA., Nussbaum J; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA., Tweedt I; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA., Haake DA; Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.; The David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Galloway RL; Centers for Disease Control and Prevention, Atlanta, GA, USA., Monzón J; Natural Science Division, Pepperdine University, Malibu, CA, USA., Riley SPD; Santa Monica Mountains National Recreation Area, National Park Service, Thousand Oaks, CA, USA., Sikich JA; Santa Monica Mountains National Recreation Area, National Park Service, Thousand Oaks, CA, USA., Brown J; Santa Monica Mountains National Recreation Area, National Park Service, Thousand Oaks, CA, USA., Friscia A; Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA., Sahl JW; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA., Wagner DM; The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA., Lynch JW; Institute for Society and Genetics, University of California, Los Angeles, CA, USA., Prager KC; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA., Lloyd-Smith JO; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA. jlloydsmith@ucla.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Sep 01; Vol. 13 (1), pp. 14368. Date of Electronic Publication: 2023 Sep 01.
DOI: 10.1038/s41598-023-40322-2
Abstrakt: Leptospirosis, the most widespread zoonotic disease in the world, is broadly understudied in multi-host wildlife systems. Knowledge gaps regarding Leptospira circulation in wildlife, particularly in densely populated areas, contribute to frequent misdiagnoses in humans and domestic animals. We assessed Leptospira prevalence levels and risk factors in five target wildlife species across the greater Los Angeles region: striped skunks (Mephitis mephitis), raccoons (Procyon lotor), coyotes (Canis latrans), Virginia opossums (Didelphis virginiana), and fox squirrels (Sciurus niger). We sampled more than 960 individual animals, including over 700 from target species in the greater Los Angeles region, and an additional 266 sampled opportunistically from other California regions and species. In the five target species seroprevalences ranged from 5 to 60%, and infection prevalences ranged from 0.8 to 15.2% in all except fox squirrels (0%). Leptospira phylogenomics and patterns of serologic reactivity suggest that mainland terrestrial wildlife, particularly mesocarnivores, could be the source of repeated observed introductions of Leptospira into local marine and island ecosystems. Overall, we found evidence of widespread Leptospira exposure in wildlife across Los Angeles and surrounding regions. This indicates exposure risk for humans and domestic animals and highlights that this pathogen can circulate endemically in many wildlife species even in densely populated urban areas.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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