Spontaneous baroreflex sensitivity is attenuated in male UCD-type 2 diabetes mellitus rats: A link between metabolic and autonomic dysfunction.

Autor: Samora M; Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, United States., Huo Y; Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, United States., McCuller RK; Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, United States., Chidurala S; Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, United States., Stanhope KL; Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California Davis, Davis, CA, United States., Havel PJ; Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California Davis, Davis, CA, United States., Stone AJ; Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, United States., Harrison ML; Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, United States. Electronic address: michelle.harrison@utexas.edu.
Jazyk: angličtina
Zdroj: Autonomic neuroscience : basic & clinical [Auton Neurosci] 2023 Nov; Vol. 249, pp. 103117. Date of Electronic Publication: 2023 Aug 23.
DOI: 10.1016/j.autneu.2023.103117
Abstrakt: Patients with type 2 diabetes mellitus (T2DM) have impaired arterial baroreflex function, which may be linked to the co-existence of obesity. However, the role of obesity and its related metabolic impairments on baroreflex dysfunction in T2DM is unknown. This study aimed to investigate the role of visceral fat and adiponectin, the most abundant cytokine produced by adipocytes, on baroreflex dysfunction in T2DM rats. Experiments were performed in adult male UCD-T2DM rats assigned to the following experimental groups (n = 6 in each): prediabetic (Pre), diabetes-onset (T0), 4 weeks after onset (T4), and 12 weeks after onset (T12). Age-matched healthy Sprague-Dawley rats were used as controls. Rats were anesthetized and blood pressure was directly measured on a beat-to-beat basis to assess spontaneous baroreflex sensitivity (BRS) using the sequence technique. Dual-energy X-ray absorptiometry (DEXA) was used to assess body composition. Data are presented as mean ± SD. BRS was significantly lower in T2DM rats compared with controls at T0 (T2D: 3.7 ± 3.2 ms/mmHg vs Healthy: 16.1 ± 8.4 ms/mmHg; P = 0.01), but not at T12 (T2D: 13.4 ± 8.1 ms/mmHg vs Healthy: 9.2 ± 6.0 ms/mmHg; P = 0.16). T2DM rats had higher visceral fat mass, adiponectin, and insulin concentrations compared with control rats (all P < 0.01). Changes in adiponectin and insulin concentrations over the measured time-points mirrored one another and were opposite those of the BRS in T2DM rats. These findings demonstrate that obesity-related metabolic impairments may contribute to an attenuated spontaneous BRS in T2DM, suggesting a link between metabolic and autonomic dysfunction.
Competing Interests: Declaration of competing interest The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(Published by Elsevier B.V.)
Databáze: MEDLINE
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