Improvements in Sperm Motility Following Low- or High-Intensity Dietary Interventions in Men With Obesity.

Autor:	Sharma A; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Papanikolaou N; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Abou Sherif S; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Dimakopolou A; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Thaventhiran T; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Go C; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Holtermann Entwistle O; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Brown A; Centre for Obesity Research, University College London, London, UK., Luo R; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Jha R; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Prakash A; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Khalifa D; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Lewis H; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Ramaraju S; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Leeds AR; Clinical Research Unit, Parker Institute, Frederiksberg Hospital, Copenhagen, Denmark., Chahal H; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Purkayastha S; Department of General and Bariatric Surgery, Imperial College Healthcare NHS Trust, St. Mary's Hospital, London, UK., Henkel R; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Minhas S; Department of Urology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, Hammersmith, London, UK., Frost G; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Dhillo WS; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK., Jayasena CN; Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 0NN, UK.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Jan 18; Vol. 109 (2), pp. 449-460.
DOI:	10.1210/clinem/dgad523
Abstrakt:	Introduction: Obesity increases risks of male infertility, but bariatric surgery does not improve semen quality. Recent uncontrolled studies suggest that a low-energy diet (LED) improves semen quality. Further evaluation within a randomized, controlled setting is warranted. Methods: Men with obesity (18-60 years) with normal sperm concentration (normal count) (n = 24) or oligozoospermia (n = 43) were randomized 1:1 to either 800 kcal/day LED for 16 weeks or control, brief dietary intervention (BDI) with 16 weeks' observation. Semen parameters were compared at baseline and 16 weeks. Results: Mean age of men with normal count was 39.4 ± 6.4 in BDI and 40.2 ± 9.6 years in the LED group. Mean age of men with oligozoospermia was 39.5 ± 7.5 in BDI and 37.7 ± 6.6 years in the LED group. LED caused more weight loss than BDI in men with normal count (14.4 vs 6.3 kg; P < .001) and men with oligozoospermia (17.6 vs 1.8 kg; P < .001). Compared with baseline, in men with normal count total motility (TM) increased 48 ± 17% to 60 ± 10% (P < .05) after LED, and 52 ± 8% to 61 ± 6% (P < .0001) after BDI; progressive motility (PM) increased 41 ± 16% to 53 ± 10% (P < .05) after LED, and 45 ± 8% to 54 ± 65% (P < .001) after BDI. In men with oligozoospermia compared with baseline, TM increased 35% [26] to 52% [16] (P < .05) after LED, and 43% [28] to 50% [23] (P = .0587) after BDI; PM increased 29% [23] to 46% [18] (P < .05) after LED, and 33% [25] to 44% [25] (P < .05) after BDI. No differences in postintervention TM or PM were observed between LED and BDI groups in men with normal count or oligozoospermia. Conclusion: LED or BDI may be sufficient to improve sperm motility in men with obesity. The effects of paternal dietary intervention on fertility outcomes requires investigation. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
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