Pre-polycystic ovary syndrome and polymenorrhoea as new facets of polycystic ovary syndrome (PCOS): Evidences from a single centre data set.

Autor: Ganie MA; Department of Endocrinology, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India.; Department of Clinical Research, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Rashid A; Department of Clinical Research, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Baba MS; Department of Endocrinology, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Zargar MA; Department of Life Sciences, Central University of Kashmir, Ganderbal, India., Wani IA; Department of Clinical Research, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Nisar S; Department of Medicine, Government Medical College, Srinagar, India., Wani IA; Department of Clinical Research, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Douhath S; Department of Clinical Research, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Sriwastawa M; Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA., Geer MI; Department of Pharmacology, University of Kashmir, Srinagar, India., Asrar MM; Department of Clinical Research, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Kutum R; Department of Computer Science, Ashoka University, Sonepath, India.; Department of Computer Science, Trivedi School of Biosciences, Ashoka University, Sonepath, India., Hassan S; Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology (Deemed University), Chennai, India., Khan S; Department of Lab Medicine, AIIMS New Delhi, New Delhi, India., Rafi W; Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India., Bhat DA; Department of Clinical Biochemistry, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Showkat W; Department of Clinical Research, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Sahar T; Department of Clinical Research, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Choh NA; Department of Radiodiagnosis and Imaging, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Khurshid R; Department of Obstetrics and Gynecology, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Mudassar S; Department of Clinical Biochemistry, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Shah ZA; Department of Immunology and Molecular Medicine, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Shabir I; Department of Biochemistry, Iowa State University, Ames, Iowa, USA., Sofi SA; Department of Radiodiagnosis and Imaging, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Gupta N; Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India., Hafeez I; Department of Cardiology, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India., Sreenivas V; Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Jazyk: angličtina
Zdroj: Clinical endocrinology [Clin Endocrinol (Oxf)] 2023 Dec; Vol. 99 (6), pp. 566-578. Date of Electronic Publication: 2023 Sep 01.
DOI: 10.1111/cen.14964
Abstrakt: Objective: Polycystic ovary syndrome (PCOS) is a complex disorder with diverse metabolic implications. Diagnosis typically relies on oligo-amenorrhoea (OA), hyperandrogenism (HA), and polycystic ovarian morphology (PCOM). However, the role of polymenorrhoea in PCOS remains understudied. Additionally, limited information exists regarding metabolic disturbances in women with partial PCOS phenotypes that do not meet diagnostic criteria. This extensive database aims to provide substantial evidence on the metabolic implications of polymenorrhoea and partial PCOS phenotypes.
Design: Prospective observational study.
Patients and Measurements: In this single-centre study, 6463 women with PCOS-like characteristics and 3142 age-matched healthy women were included. The study compared clinical (anthropometry, modified Ferriman Gallwey [mFG] score), hormonal (serum testosterone), and metabolic (plasma glucose, serum lipids, insulin) characteristics between women diagnosed with PCOS, those with partial PCOS phenotypes, and the healthy control group RESULTS: In all, 5174 women met Rotterdam criteria for PCOS diagnosis, while 737 were classified as Pre-PCOS, including HA (n = 538), OA (n = 121), or PCOM (n = 78). Common clinical features included oligomenorrhoea (75.5%), hirsutism (82.9%), obesity (27.2%), hypertension (1.6%), metabolic syndrome (19.6%), and diabetes mellitus (5.6%). Women diagnosed with PCOS, HA only, and OA only exhibited higher average body mass index, plasma glucose levels (both fasting and 2 h after the oral glucose tolerance test), and lipid fractions in comparison to those with PCOM and the healthy controls. However, indices of insulin resistance were similar among women with PCOS, HA, PCOM, and OA, albeit higher than in the healthy controls. The polymenorrhoea subgroup (5.9%) had lower BMI and serum testosterone, but similar mFG score, plasma glucose, insulin, and lipid levels as the oligomenorrhoea subgroup.
Conclusion: The metabolic disturbances observed in Pre-PCOS women highlight the need to reassess diagnostic criteria. Including the polymenorrhoea subcategory in PCOS criteria is recommended due to similar metabolic dysfunctions as the oligomenorrhoea group.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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