[Steadfastly increased level of the ciliary neurotrophic factor in the blood serum within the positive therapeutic dynamics of depression as possible prognostic marker of depressive relapse].

Autor:	Uzbekov MG; Serbsky National Medical Research Center of Psychiatry and Narcology - Moscow Research Institute of Psychiatry, Moscow, Russia., Shikhov SN; Serbsky National Medical Research Center of Psychiatry and Narcology - Moscow Research Institute of Psychiatry, Moscow, Russia., Kryukov VV; Serbsky National Medical Research Center of Psychiatry and Narcology - Moscow Research Institute of Psychiatry, Moscow, Russia., Krasnov VN; Serbsky National Medical Research Center of Psychiatry and Narcology - Moscow Research Institute of Psychiatry, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2023; Vol. 123 (8), pp. 120-123.
DOI:	10.17116/jnevro2023123081120
Abstrakt:	Objective: To study a role of the ciliary neurotrophic factor (CNTF) in the pathogenesis of depression and its prognostic significance in dynamics of the antidepressant therapy. Material and Methods: CNTF level was investigated in the blood serum of patients with melancholic depression ( n =32) before the start of therapy and after 30 days, when improvement was achieved by at least 75% of baseline scores on the Hamilton Depression Rating Scale. Results: Steadfastly increased level of CNTF in the blood serum of patients with melancholic depression compared with the control, remaining practically unchanged with an obvious improvement in the condition - 732.2±126.5 and 679.1±63.1 pg/ml of serum, respectively ( p >0.05). Conclusion: The initially elevated level of CNTP indicates its probable significance in the pathogenesis of depression; persistently high serum CNTP level, despite clinical improvement during therapy, can serve as a predictor of the stability of the biological mechanisms of recurrent depressive disorder with a continuing risk of another relapse of a depressive episode.
Databáze:	MEDLINE
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