Antimicrobial Properties and Substantivity of Gentamicin, Amoxicillin and Metronidazole (GAM) Antibiotic Solution with Chitosan as a Root Canal Irrigant - A Preliminary Study.

Autor:	Parakh K; Department of Pedodontics and Preventive Dentistry, Chhattisgarh Dental College and Research Institute, Rajnandgaon, Chhattisgarh, India., Shetty RM; Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, UAE.; Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, UAE.; Adjunct Faculty, Dept. of Pediatric and Preventive Dentistry, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research (Declared as Deemed-to-be-University), Wardha, Maharashtra, India., Shetty S; Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE., Desai V; Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, UAE.; Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, UAE., Shetty S; Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah Sharjah, Sharjah, UAE., Al Jadaa A; Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, UAE.; Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, UAE., Jain S; Department of Pedodontics and Preventive Dentistry, Pacific Dental College and Research Institute Centre, Udaipur, Rajasthan, India., Vannala V; Department of Preventive Dental Science, Gulf Medical University, Ajman, UAE.
Jazyk:	angličtina
Zdroj:	Journal of pharmacy & bioallied sciences [J Pharm Bioallied Sci] 2023 Jul; Vol. 15 (Suppl 1), pp. S341-S345. Date of Electronic Publication: 2023 Jul 05.
DOI:	10.4103/jpbs.jpbs_500_22
Abstrakt:	Irrigation is one of the steps that is very crucial in a high-quality endodontic treatment. Hence, irrigant with good substantivity is essential which must not only be effective for the dissolution of the organic tissues but also effectively eliminate bacterial contamination. The aim of the study was to investigate and compare the antimicrobial efficacy of gentamicin, amoxicillin, and metronidazole (GAM) antibiotic solution, chitosan and their combination (GAMC), and analyze their sustained release property. Mueller-Hinton agar medium was inoculated with E. faecalis . The medicaments were then poured at the center of the plate in the prepared wells and incubated at 37°C. Antibacterial property of each medicament was evaluated by measuring the diameter of the zone of inhibition at the end of 48 hours. The substantivity of GAM antibiotic solution and the GAMC was checked using an ultraviolet spectrophotometer. The GAMC demonstrated the strongest antimicrobial activity and good sustained-release properties. Distilled water showed no activity, and chlorhexidine acted as the positive control. Conclusion: The combination of gentamicin, amoxicillin, and metronidazole (GAM) solution with chitosan (GAMC) can be used as an alternative intracanal irrigant as it was found to be a potent antibacterial agent. Competing Interests: There are no conflicts of interest. (Copyright: © 2023 Journal of Pharmacy and Bioallied Sciences.)
Databáze:	MEDLINE
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