Exploring the significance of lipids in Alzheimer's disease and the potential of extracellular vesicles.

Autor: Su H; The Florey, The University of Melbourne, Parkville, Victoria, Australia.; School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia., Masters CL; The Florey, The University of Melbourne, Parkville, Victoria, Australia., Bush AI; The Florey, The University of Melbourne, Parkville, Victoria, Australia., Barnham KJ; The Florey, The University of Melbourne, Parkville, Victoria, Australia., Reid GE; School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, Victoria, Australia., Vella LJ; The Florey, The University of Melbourne, Parkville, Victoria, Australia.; Department of Surgery, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Jazyk: angličtina
Zdroj: Proteomics [Proteomics] 2024 Jun; Vol. 24 (11), pp. e2300063. Date of Electronic Publication: 2023 Aug 31.
DOI: 10.1002/pmic.202300063
Abstrakt: Lipids play a significant role in maintaining central nervous system (CNS) structure and function, and the dysregulation of lipid metabolism is known to occur in many neurological disorders, including Alzheimer's disease. Here we review what is currently known about lipid dyshomeostasis in Alzheimer's disease. We propose that small extracellular vesicle (sEV) lipids may provide insight into the pathophysiology and progression of Alzheimer's disease. This stems from the recognition that sEV likely contributes to disease pathogenesis, but also an understanding that sEV can serve as a source of potential biomarkers. While the protein and RNA content of sEV in the CNS diseases have been studied extensively, our understanding of the lipidome of sEV in the CNS is still in its infancy.
(© 2023 The Authors. PROTEOMICS published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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