Vesicoureteral reflux is associated with increased risk of chronic kidney disease: A nationwide cohort study.

Autor:	Lee SY; Department of Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan.; Department of Pathology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Lai JN; Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan.; Management office for Health Data, China Medical University Hospital, Taichung, Taiwan., Haw Y; Department of Pathology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Chiu LT; Management office for Health Data, China Medical University Hospital, Taichung, Taiwan.; School of Medicine, China Medical University, Taichung, Taiwan., Huang SM; Department of Medicine, Show Chwan Memorial Hospital, Chang Hua, Taiwan., Cheng KL; Department of Medical Imaging, China Medical University Hospital, Taichung, Taiwan., Chew FY; School of Medicine, China Medical University, Taichung, Taiwan.; Department of Medical Imaging, China Medical University Hospital, Taichung, Taiwan.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2023 Aug 25; Vol. 102 (34), pp. e34867.
DOI:	10.1097/MD.0000000000034867
Abstrakt:	The association between vesicoureteral reflux (VUR) and chronic kidney disease (CKD) risk remains unestablished. We investigated the incidence of CKD in children with VUR in Taiwan and evaluated whether they had a higher risk of CKD than the general population. A nationwide population-based cohort study was conducted among children with VUR identified using Taiwan's National Health Insurance Research Database from 2000 to 2013. VUR was defined according to the International Classification of Diseases, Ninth Revision, Clinical Modification codes. We identified the children with VUR and randomly selected comparison children according to a 1:1 ratio, matching them by age, gender, index year and comorbidity using data from the National Health Insurance Research Database. In total, 8648 children with VUR and 8648 comparison children were included. All children were followed from the study date until a diagnosis of CKD, termination of insurance, or the end of 2013. Cox proportional hazards regressions were performed to compare the hazard ratios for CKD between the 2 cohorts. Incident cases of CKD were identified. After adjustment for potential confounders, the study cohort was independently associated with a higher risk of CKD (adjusted hazard ratio, 3.78; 95% confidence interval, 2.10-7.18). This population-based cohort study indicated that children with VUR have a higher risk of CKD than those without VUR. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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