Long-Range Electron Transport Rates Depend on Wire Dimensions in Cytochrome Nanowires.
Autor: | Kulke M; MSU-DOE Plant Research Laboratory and Department of Biochemistry and Molecular Biology, Michigan State University, 612 Wilson Rd, East Lansing, MI, 48824, United States of America., Olson DM; MSU-DOE Plant Research Laboratory and Department of Biochemistry and Molecular Biology, Michigan State University, 612 Wilson Rd, East Lansing, MI, 48824, United States of America., Huang J; MSU-DOE Plant Research Laboratory and Department of Biochemistry and Molecular Biology, Michigan State University, 612 Wilson Rd, East Lansing, MI, 48824, United States of America., Kramer DM; MSU-DOE Plant Research Laboratory and Department of Biochemistry and Molecular Biology, Michigan State University, 612 Wilson Rd, East Lansing, MI, 48824, United States of America., Vermaas JV; MSU-DOE Plant Research Laboratory and Department of Biochemistry and Molecular Biology, Michigan State University, 612 Wilson Rd, East Lansing, MI, 48824, United States of America. |
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Jazyk: | angličtina |
Zdroj: | Small (Weinheim an der Bergstrasse, Germany) [Small] 2023 Dec; Vol. 19 (52), pp. e2304013. Date of Electronic Publication: 2023 Aug 31. |
DOI: | 10.1002/smll.202304013 |
Abstrakt: | The ability to redirect electron transport to new reactions in living systems opens possibilities to store energy, generate new products, or probe physiological processes. Recent work by Huang et al. showed that 3D crystals of small tetraheme cytochromes (STC) can transport electrons over nanoscopic to mesoscopic distances by an electron hopping mechanism, making them promising materials for nanowires. However, fluctuations at room temperature may distort the nanostructure, hindering efficient electron transport. Classical molecular dynamics simulations of these fluctuations at the nano- and mesoscopic scales allowed us to develop a graph network representation to estimate maximum electron flow that can be driven through STC wires. In longer nanowires, transient structural fluctuations at protein-protein interfaces tended to obstruct efficient electron transfer, but these blockages are ameliorated in thicker crystals where alternative electron transfer pathways become more efficient. The model implies that more flexible proteinprotein interfaces limit the required minimum diameter to carry currents commensurate with conventional electronics. (© 2023 The Authors. Small published by Wiley-VCH GmbH.) |
Databáze: | MEDLINE |
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