Preconception clinical factors related to adverse pregnancy outcomes in patients with systemic lupus erythematosus or primary Sjögren's syndrome: a retrospective cohort study.

Autor:	Fierro JJ; Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands.; Microbiología y Parasitología, Grupo Reproduccion, Universidad de Antioquia UdeA, Medellin, Antioquia, Colombia., Prins JR; Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands., Verstappen GM; Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands., Bootsma H; Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands., Westra J; Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands., de Leeuw K; Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands k.de.leeuw@umcg.nl.
Jazyk:	angličtina
Zdroj:	RMD open [RMD Open] 2023 Aug; Vol. 9 (3).
DOI:	10.1136/rmdopen-2023-003439
Abstrakt:	Objective: To identify preconception clinical factors associated with adverse pregnancy outcomes (APO) in patients with systemic lupus erythematosus (SLE) or primary Sjögren's syndrome (pSS). Methods: A single-centre, retrospective cohort study was conducted, which included pregnant women treated at the University Medical Center Groningen between January 2010 and August 2021 who fulfilled classification criteria for SLE or pSS. Demographic data, relevant comorbidities, disease duration, disease activity before and during pregnancy, APO, laboratory parameters and treatment regimens were recorded. Associations between the presence of APO and preconception characteristics were evaluated. Results: Our study population included 48 (70%) SLE and 21 (30%) pSS pregnancies concerning 70 fetuses (one twin). Preterm birth (n=9, 19%) was the most frequent APO in SLE pregnancies, while in pSS pregnancies this was miscarriages (n=3, 14%). There were no associations between the presence of APO in SLE pregnancies and clinical parameters, laboratory parameters or medication use prior to conception. In the pSS group, significant associations were found between the presence of APO and body mass index (p=0.010), parity (p=0.046), C4 (p=0.021) and low C4 levels (p=0.002). Conclusions: No preconception risk factors related to APO were found in SLE pregnancies, whereas preconception complement levels were associated with APO development in patients with pSS. Competing Interests: Competing interests: The authors declare that there is no conflict of interest. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu