Total-Body Perfusion Imaging with [ 11 C]-Butanol.
| Autor: | Li EJ; Department of Biomedical Engineering, UC Davis, Davis, California., López JE; Department of Internal Medicine, Division of Cardiovascular Medicine, UC Davis Health, UC Davis, Sacramento, California; and., Spencer BA; Department of Biomedical Engineering, UC Davis, Davis, California., Abdelhafez Y; Department of Radiology, UC Davis Health, UC Davis, Sacramento, California., Badawi RD; Department of Biomedical Engineering, UC Davis, Davis, California.; Department of Radiology, UC Davis Health, UC Davis, Sacramento, California., Wang G; Department of Radiology, UC Davis Health, UC Davis, Sacramento, California., Cherry SR; Department of Biomedical Engineering, UC Davis, Davis, California; srcherry@ucdavis.edu.; Department of Radiology, UC Davis Health, UC Davis, Sacramento, California. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2023 Nov; Vol. 64 (11), pp. 1831-1838. Date of Electronic Publication: 2023 Aug 31. |
| DOI: | 10.2967/jnumed.123.265659 |
| Abstrakt: | Tissue perfusion can be affected by physiology or disease. With the advent of total-body PET, quantitative measurement of perfusion across the entire body is possible. [ 11 C]-butanol is a perfusion tracer with a superior extraction fraction compared with [ 15 O]-water and [ 13 N]-ammonia. To develop the methodology for total-body perfusion imaging, a pilot study using [ 11 C]-butanol on the uEXPLORER total-body PET/CT scanner was conducted. Methods: Eight participants (6 healthy volunteers and 2 patients with peripheral vascular disease [PVD]) were injected with a bolus of [ 11 C]-butanol and underwent 30-min dynamic acquisitions. Three healthy volunteers underwent repeat studies at rest (baseline) to assess test-retest reproducibility; 1 volunteer underwent paired rest and cold pressor test (CPT) studies. Changes in perfusion were measured in the paired rest-CPT study. For PVD patients, local changes in perfusion were investigated and correlated with patient medical history. Regional and parametric kinetic analysis methods were developed using a 1-tissue compartment model and leading-edge delay correction. Results: Estimated baseline perfusion values ranged from 0.02 to 1.95 mL·min -1 ·cm -3 across organs. Test-retest analysis showed that repeat baseline perfusion measurements were highly correlated (slope, 0.99; Pearson r = 0.96, P < 0.001). For the CPT subject, the largest regional increases were in skeletal muscle (psoas, 142%) and the myocardium (64%). One of the PVD patients showed increased collateral vessel growth in the calf because of a peripheral stenosis. Comorbidities including myocardial infarction, hypothyroidism, and renal failure were correlated with variations in organ-specific perfusion. Conclusion: This pilot study demonstrates the ability to obtain reproducible measurements of total-body perfusion using [ 11 C]-butanol. The methods are sensitive to local perturbations in flow because of physiologic stressors and disease. (© 2023 by the Society of Nuclear Medicine and Molecular Imaging.) |
| Databáze: | MEDLINE |
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