Developing and testing a COVID-19 vaccination acceptance intervention: A pragmatic trial comparing vaccine acceptance intervention vs usual care - Rationale, methods, and implementation.

Autor: Pyne JM; Center for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare System, 2200 Fort Roots Drive, North Little Rock, AR, United States of America; South Central Mental Illness Research, Education and Clinical Center, Central Arkansas Veterans Healthcare System, 2200 Fort Roots Drive, North Little Rock, AR, United States of America; Psychiatric Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America. Electronic address: jeffrey.pyne@va.gov., Seal KH; Integrative Health Service, San Francisco VA Healthcare System, 4150 Clement Street, San Francisco, CA, United States of America; Departments of Medicine and Psychiatry, University of California San Francisco, San Francisco, CA, United States of America., Manuel JK; Integrative Health Service, San Francisco VA Healthcare System, 4150 Clement Street, San Francisco, CA, United States of America; Department of Psychiatry, University of California, 675 18th Street San Francisco, San Francisco, CA, United States of America., DeRonne B; Minneapolis VA Health Care System, One Veterans Drive, Minneapolis, MN, United States of America; Center for Care Delivery and Outcomes Research, 5445 Minnehaha Avenue South, Building 9, Minneapolis, MN, United States of America., Oliver KA; Center for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare System, 2200 Fort Roots Drive, North Little Rock, AR, United States of America., Bertenthal D; Integrative Health Service, San Francisco VA Healthcare System, 4150 Clement Street, San Francisco, CA, United States of America., Esserman D; Department of Biostatistics, Yale School of Public Health, New Haven, CT, United States of America., Purcell N; Integrative Health Service, San Francisco VA Healthcare System, 4150 Clement Street, San Francisco, CA, United States of America; Department of Social and Behavioral Sciences, University of California, 490 Illinois St., San Francisco, CA, United States of America., Petrakis BA; Center for Healthcare Organization and Implementation Research, VA Bedford Healthcare System, 200 Springs Road, Bedford, MA, United States of America., Elwy AR; Center for Healthcare Organization and Implementation Research, VA Bedford Healthcare System, 200 Springs Road, Bedford, MA, United States of America; Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Box G-BH, Providence, RI, United States of America.
Jazyk: angličtina
Zdroj: Contemporary clinical trials [Contemp Clin Trials] 2023 Oct; Vol. 133, pp. 107325. Date of Electronic Publication: 2023 Aug 29.
DOI: 10.1016/j.cct.2023.107325
Abstrakt: Background: COVID-19 has resulted in significant disability and loss of life. COVID-19 vaccines effectively prevent severe illness, hospitalization, and death. Nevertheless, many people remain hesitant to accept vaccination. Veterans perceive healthcare providers (HCP) and staff as trusted vaccine information sources and thereby are well suited to initiate vaccine discussions. The overall objective of this study is to implement and test a virtual COVID-19 Vaccine Acceptance Intervention (VAI) training that is informed by motivational interviewing (MI) techniques.
Methods: The VAI training is being delivered to VA HCPs and staff within a Hybrid Type 2 pragmatic implementation-effectiveness trial using Implementation Facilitation as the implementation strategy. The implementation team includes external facilitators paired with VA Healthcare System (VAHCS)-level internal facilitators. The trial has three aims: 1) Examine the effectiveness of the VAI versus usual care on unvaccinated veterans' vaccination rates in a one-year cluster randomized controlled trial, with randomization at the level of VAHCS. 2) Determine factors associated with veterans' decisions to accept or decline primary COVID-19 vaccination, and better understand how these factors influence vaccination decisions, through survey and qualitative data; and 3) Use qualitative interviews with HCPs and staff from clinics with high and low vaccination rates to learn what was helpful and not helpful about the VAI and implementation strategies.
Conclusion: This is the first multisite randomized controlled trial to test an MI-informed vaccine acceptance intervention to improve COVID-19 vaccine acceptance. Information gained can be used to inform healthcare systems' approaches to improve future vaccination and other public health campaigns.
Clinicaltrials: gov Identifier: NCT05027464.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE