Sex differences of microglia in the healthy brain from embryonic development to adulthood and across lifestyle influences.

Autor: Bobotis BC; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada., Braniff O; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada., Gargus M; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada., Akinluyi ET; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada; Department of Pharmacology and Therapeutics, Afe Babalola University, Ado-Ekiti, Nigeria., Awogbindin IO; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada; Neuroimmunology Group, Molecular Drug Metabolism and Toxicology Laboratory, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria., Tremblay MÈ; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada; Neurosciences Axis, Centre de Recherche du CHU de Québec, Université Laval, Québec, QC, Canada; Department of Molecular Medicine, Université Laval, Québec, QC, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada. Electronic address: evetremblay@uvic.ca.
Jazyk: angličtina
Zdroj: Brain research bulletin [Brain Res Bull] 2023 Oct 01; Vol. 202, pp. 110752. Date of Electronic Publication: 2023 Aug 29.
DOI: 10.1016/j.brainresbull.2023.110752
Abstrakt: Microglia, the central nervous system innate immune cells, play a critical role in maintaining a homeostatic environment in the brain throughout life. These cells exhibit an impressive range of functions and characteristics that help to ensure proper functioning of the brain. Notably, microglia can present differences in their genetic and physical traits, which can be influenced by a range of factors, including age, environmental exposures, disease, and sex. Remarkably, microglia have been found to express receptors for sex hormones, suggesting that these hormones may play a role in modulating microglial behavior and potentially contribute to sex differences. Additionally, sex-chromosomal factors were shown to impact microglial genetics and functioning. In this review, we will examine how microglial responses in homeostasis are impacted by their interaction with sex hormones and sex chromosomes. Specifically, our investigation will focus on examining this interaction from embryonic development to adulthood, and the influence of lifestyle elements on various microglial features, including density and distribution, morphology, transcriptome, and proteome.
Competing Interests: Declaration of Competing Interest Authors report no conflict of interest.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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