Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics.

Autor: Hollingsworth BD; Department of Entomology, Cornell University, Ithaca, New York, United States of America.; Cornell Institute for Host Microbe Interaction and Disease, Cornell University, Ithaca, New York, United States of America., Grubaugh ND; Yale School of Public Health, New Haven, Connecticut, United States of America.; Yale University, New Haven, Connecticut, United States of America., Lazzaro BP; Department of Entomology, Cornell University, Ithaca, New York, United States of America.; Cornell Institute for Host Microbe Interaction and Disease, Cornell University, Ithaca, New York, United States of America., Murdock CC; Department of Entomology, Cornell University, Ithaca, New York, United States of America.; Cornell Institute for Host Microbe Interaction and Disease, Cornell University, Ithaca, New York, United States of America.; Northeast Regional Center for Excellence in Vector-borne Diseases, Cornell University, Ithaca, New York, United States of America.
Jazyk: angličtina
Zdroj: PLoS pathogens [PLoS Pathog] 2023 Aug 31; Vol. 19 (8), pp. e1011588. Date of Electronic Publication: 2023 Aug 31 (Print Publication: 2023).
DOI: 10.1371/journal.ppat.1011588
Abstrakt: Several aspects of mosquito ecology that are important for vectored disease transmission and control have been difficult to measure at epidemiologically important scales in the field. In particular, the ability to describe mosquito population structure and movement rates has been hindered by difficulty in quantifying fine-scale genetic variation among populations. The mosquito virome represents a possible avenue for quantifying population structure and movement rates across multiple spatial scales. Mosquito viromes contain a diversity of viruses, including several insect-specific viruses (ISVs) and "core" viruses that have high prevalence across populations. To date, virome studies have focused on viral discovery and have only recently begun examining viral ecology. While nonpathogenic ISVs may be of little public health relevance themselves, they provide a possible route for quantifying mosquito population structure and dynamics. For example, vertically transmitted viruses could behave as a rapidly evolving extension of the host's genome. It should be possible to apply established analytical methods to appropriate viral phylogenies and incidence data to generate novel approaches for estimating mosquito population structure and dispersal over epidemiologically relevant timescales. By studying the virome through the lens of spatial and genomic epidemiology, it may be possible to investigate otherwise cryptic aspects of mosquito ecology. A better understanding of mosquito population structure and dynamics are key for understanding mosquito-borne disease ecology and methods based on ISVs could provide a powerful tool for informing mosquito control programs.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Hollingsworth et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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