Altered plasma metabolite levels can be detected years before a glioma diagnosis.

Autor:	Löding S; Department of Chemistry., Andersson U; Biobank Reserach Unit, and.; Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden., Kaaks R; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Pala V; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Urbarova I; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway., Amiano P; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Ministry of Health of the Basque Government, Public Health Laboratory in Gipuzkoa, San Sebastián, Spain.; Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastián, Spain., Colorado-Yohar SM; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain.; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia., Guevara M; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Institute of Public and Labor Health and Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Heath AK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Chatziioannou AC; Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), Lyon, France., Johansson M; Genomic Epidemiology Branch, IARC, Lyon, France., Nyberg L; Department of Radiation Sciences, Diagnositc Radiology, and.; Department of Integrative Medical Biology (IMB), Umeå University, Umeå, Sweden., Antti H; Department of Chemistry., Björkblom B; Department of Chemistry., Melin B; Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Jazyk:	angličtina
Zdroj:	JCI insight [JCI Insight] 2023 Oct 09; Vol. 8 (19). Date of Electronic Publication: 2023 Oct 09.
DOI:	10.1172/jci.insight.171225
Abstrakt:	Genetic and metabolic changes in tissue and blood are reported to occur several years before glioma diagnosis. Since gliomas are currently detected late, a liquid biopsy for early detection could affect the quality of life and prognosis of patients. Here, we present a nested case-control study of 550 prediagnostic glioma cases and 550 healthy controls from the Northern Sweden Health and Disease study (NSHDS) and the European Prospective Investigation into Cancer and Nutrition (EPIC) study. We identified 93 significantly altered metabolites related to glioma development up to 8 years before diagnosis. Out of these metabolites, a panel of 20 selected metabolites showed strong disease correlation and a consistent progression pattern toward diagnosis in both the NSHDS and EPIC cohorts, and they separated future cases from controls independently of biological sex. The blood metabolite panel also successfully separated both lower-grade glioma and glioblastoma cases from controls, up to 8 years before diagnosis in patients within the NSHDS cohort and up to 2 years before diagnosis in EPIC. Pathway enrichment analysis detected metabolites related to the TCA cycle, Warburg effect, gluconeogenesis, and cysteine, pyruvate, and tyrosine metabolism as the most affected.
Databáze:	MEDLINE
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