[Autologous bone implant for reconstructive surgery after decompressive craniectomy in children].

Autor:	Semenova ZB; Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russia., Salimon AI; Skoltech, Moscow, Russia., Korsunsky AM; Skoltech, Moscow, Russia., Melnikov AV; Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russia., Sadykova YA; Skoltech, Moscow, Russia., Marshintsev AV; Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russia., Statnik ES; Skoltech, Moscow, Russia., Lukyanov VI; Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russia.
Jazyk:	English; Russian
Zdroj:	Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 2023; Vol. 87 (4), pp. 58-65.
DOI:	10.17116/neiro20238704158
Abstrakt:	The concept of post-traumatic skull defect closure is based on restoration of anatomical relationships for the maximum possible recovery of brain function, i.e. it is considered as a stage of surgical rehabilitation. The choice of implants in pediatric patients is limited. In this regard, the «gold standard» is still autologous bone implant. Material and Methods: We propose a method for storage and sterilization of autologous bone implant. The last one implies keeping at a temperature of -80 ˚C with sterilization in a vacuum chamber filled with hydrogen peroxide vapors of biocidal plasma medium. Sterilization is provided by 45-minute cycle immediately before surgery. We report skull defect closure using autologous bone implants in 79 patients. Evaluation of effectiveness of storage and sterilization of autologous bone implant included analysis of mechanical properties of bone after sterilization, intra-operative microbiological monitoring, incidence of infections in early postoperative period, follow-up with assessment of resorption. Results: Early infectious complications occurred in 2 patients (2.5%). Complete resorption with redo surgery occurred in 6 (10.1%) cases. Sterilization in low-temperature plasma of hydrogen peroxide changes mechanical properties of the bone, increases durability under compressive stresses and decreases durability under tensile conditions. This does not affect functional tasks of autologous bone. The proposed method of storage and sterilization is accompanied by low risk of infections and resorption. Storage of autologous bone implant at a temperature of -80 ˚C with subsequent sterilization in low-temperature plasma of hydrogen peroxide can be considered as a safe and effective method for skull defect closure in children after decompressive surgery.
Databáze:	MEDLINE
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