Spatial transcriptomics of a giant pilomatricoma.

Autor: Patil AT; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Bennett DD; Department of Dermatology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Xu J; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Weisman P; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Matson DR; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jazyk: angličtina
Zdroj: Journal of cutaneous pathology [J Cutan Pathol] 2023 Nov; Vol. 50 (11), pp. 963-970. Date of Electronic Publication: 2023 Aug 30.
DOI: 10.1111/cup.14524
Abstrakt: Pilomatricomas (PMs) are common benign adnexal tumors that show a predilection for the head and neck region and are characterized at the molecular level by activating mutations in the beta-catenin (CTNNB1) gene. Giant PMs are a rare histopathological variant, according to the World Health Organization, which are defined by a size greater than 4 cm and are reported to show upregulation of yes-associated protein compared to PMs of typical 1-3 cm size. We describe the case of a 67-year-old man with an 8 cm giant PM involving his temporal scalp, whose PM we characterized by 10X spatial gene expression analysis. This revealed five total transcriptomic clusters, including four distinct clusters within the giant PM, each with a unique transcriptional pattern of hair follicle-related factors, keratin gene expression, and beta-catenin pathway activity.
(© 2023 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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