Breast stiffness, a risk factor for cancer and the role of radiology for diagnosis.

Autor: Tarchi SM; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Milan, Italy., Pernia Marin M; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA. monicapernia.md@gmail.com., Hossain MM; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Salvatore M; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA.
Jazyk: angličtina
Zdroj: Journal of translational medicine [J Transl Med] 2023 Aug 30; Vol. 21 (1), pp. 582. Date of Electronic Publication: 2023 Aug 30.
DOI: 10.1186/s12967-023-04457-0
Abstrakt: Over the last five decades, breast density has been associated with increased risk of developing breast cancer. Mammographically dense breasts are considered those belonging to the heterogeneously dense breasts, and extremely dense breasts subgroups according to the American College of Radiology's Breast Imaging Reporting and Data System (BI-RADS). There is a statistically significant correlation between the increased mammographic density and the presence of more glandular tissue alone. However, the strength of this correlation is weak. Although the mechanisms driving breast density-related tumor initiation and progression are still unknown, there is evidence suggesting that certain molecular pathways participating in epithelial-stromal interactions may play a pivotal role in the deposition of fibrillar collagen, increased matrix stiffness, and cell migration that favor breast density and carcinogenesis. This article describes these molecular mechanisms as potential "landscapers" for breast density-related cancer. We also introduce the term "Breast Compactness" to reflect collagen density of breast tissue on chest CT scan and the use of breast stiffness measurements as imaging biomarkers for breast cancer screening and risk stratification.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
Databáze: MEDLINE
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