Longitudinal effects of FTO gene polymorphism on body composition, cardiorespiratory fitness, physical activity, inflammatory markers, and cardiovascular risk in children and adolescents. "The UP & DOWN study".

Autor: Mier-Mota J; Salus Infirmorum, University of Cádiz, Cadiz, Spain., Ponce-González JG; ExPhy Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain., Perez-Bey A; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.; GALENO Research Group, Department of Physical Education, School of Education, University of Cádiz, Puerto Real, Spain., Cabanas-Sánchez V; Department of Preventive Medicine and Public Health. School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.; CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain.; IMDEA-Food Institute. CEI UAM+CSIC, Madrid, Spain., Veiga-Núñez O; Department of Preventive Medicine and Public Health. School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Santiago-Dorrego C; Faculty of Physical Activity, Sport Sciences and Physiotherapy, Universidad Europea de Madrid, Madrid, Spain., Gómez-Gallego F; Department of Basic Health Sciences, Universidad Rey Juan Carlos, Madrid, Spain., Castro-Piñero J; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.; GALENO Research Group, Department of Physical Education, School of Education, University of Cádiz, Puerto Real, Spain.
Jazyk: angličtina
Zdroj: Scandinavian journal of medicine & science in sports [Scand J Med Sci Sports] 2023 Nov; Vol. 33 (11), pp. 2261-2272. Date of Electronic Publication: 2023 Aug 30.
DOI: 10.1111/sms.14469
Abstrakt: The role of polymorphism rs9939609 of the FTO gene has been related with fat mass and cardiovascular risk in adults, but it remains unclear in children and adolescents. Hence, the main aim of this study was to determine the FTO polymorphism effects on body composition, cardiorespiratory fitness (CRF), physical activity (PA), inflammatory markers, and cardiovascular risk both in cross-sectional analysis and after two-years of follow-up in children and adolescents. A total of 2129 participants were included in this study. The rs9939609 polymorphism was genotyped. Body composition measurements, CRF, and moderate-to-vigorous PA (MVPA) were determined at baseline and after two-year of follow-up. Moreover, plasma leptin and adiponectin were also determined as inflammatory markers. Furthermore, an index of cardiovascular disease risk factors (CVDRF-I) was calculated. Codominant (TT vs. TA vs. AA) and dominant (AA+AT vs. TT) models were applied for statistical analysis. The results showed a main effect of the FTO genotype on body composition measures in both first and third year (p < 0.05), with lower adiposity in TT compared with AA or AA+AT group. These differences were maintained after accounting for pubertal maturity, sex, age, VO 2 max, and MVPA. Moreover, lower leptin level was observed in TT compared to AA+AT group in the third year. An interaction in Gene*Time*Sex was found in height and neck circumference in dominant model (p = 0.047; p = 0.020, respectively). No differences were found in CRF, MVPA nor CVDRF-I between groups. Hence, homozygous TT allele could be a protective factor against weight gain from early childhood.
(© 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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