Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease.

Autor: Hoskinson C; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Dai DLY; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada., Del Bel KL; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada., Becker AB; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada., Moraes TJ; Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada., Mandhane PJ; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Finlay BB; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada., Simons E; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada., Kozyrskyj AL; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Azad MB; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.; Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada., Subbarao P; Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Petersen C; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada., Turvey SE; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada. sturvey@cw.bc.ca.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Aug 29; Vol. 14 (1), pp. 4785. Date of Electronic Publication: 2023 Aug 29.
DOI: 10.1038/s41467-023-40336-4
Abstrakt: Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur in parallel; thus, the conformation of the microbiome may determine if tolerant immune programming arises within the infant. Here we show, using deeply phenotyped participants in the CHILD birth cohort (n = 1115), that there are early-life influences and microbiome features which are uniformly associated with four distinct allergic diagnoses at 5 years: atopic dermatitis (AD, n = 367), asthma (As, n = 165), food allergy (FA, n = 136), and allergic rhinitis (AR, n = 187). In a subset with shotgun metagenomic and metabolomic profiling (n = 589), we discover that impaired 1-year microbiota maturation may be universal to pediatric allergies (AD p = 0.000014; As p = 0.0073; FA p = 0.00083; and AR p = 0.0021). Extending this, we find a core set of functional and metabolic imbalances characterized by compromised mucous integrity, elevated oxidative activity, decreased secondary fermentation, and elevated trace amines, to be a significant mediator between microbiota maturation at age 1 year and allergic diagnoses at age 5 years (β indirect  = -2.28; p = 0.0020). Microbiota maturation thus provides a focal point to identify deviations from normative development to predict and prevent allergic disease.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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