Postoperative [ 68 Ga]Ga-DOTA-TATE PET/CT imaging is prognostic for progression-free survival in meningioma WHO grade 1.

Autor: Teske N; Department of Neurosurgery, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany. Nico.Teske@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany. Nico.Teske@med.uni-muenchen.de., Biczok A; Department of Neurosurgery, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany., Quach S; Department of Neurosurgery, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany., Dekorsy FJ; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany., Forbrig R; Institute of Neuroradiology, LMU University Hospital, LMU Munich, Munich, Germany., Bodensohn R; Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany., Niyazi M; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany.; Bavarian Center for Cancer Research (BZKF), Erlangen, Germany., Tonn JC; Department of Neurosurgery, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany., Albert NL; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany., Schichor C; Department of Neurosurgery, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany., Ueberschaer M; Department of Neurosurgery, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany. Moritz.Ueberschaer@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany. Moritz.Ueberschaer@med.uni-muenchen.de.
Jazyk: angličtina
Zdroj: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2023 Dec; Vol. 51 (1), pp. 206-217. Date of Electronic Publication: 2023 Aug 29.
DOI: 10.1007/s00259-023-06400-3
Abstrakt: Purpose: Tumor resection represents the first-line treatment for symptomatic meningiomas, and the extent of resection has been shown to be of prognostic importance. Assessment of tumor remnants with somatostatin receptor PET proves to be superior to intraoperative estimation with Simpson grading or MRI. In this preliminary study, we evaluate the prognostic relevance of postoperative PET for progression-free survival in meningiomas.
Methods: We conducted a post hoc analysis on a prospective patient cohort with resected meningioma WHO grade 1. Patients received postoperative MRI and [ 68 Ga]Ga-DOTA-TATE PET/CT and were followed regularly with MRI surveillance scans for detection of tumor recurrence/progression.
Results: We included 46 patients with 49 tumors. The mean age at diagnosis was 57.8 ± 1.7 years with a male-to-female ratio of 1:1.7. Local tumor progression occurred in 7/49 patients (14%) after a median follow-up of 52 months. Positive PET was associated with an increased risk for progression (*p = 0.015) and a lower progression-free survival (*p = 0.029), whereas MRI was not. 20 out of 20 patients (100%) with negative PET findings remained recurrence-free. The location of recurrence/progression on MRI was adjacent to regions where postoperative PET indicated tumor remnants in all cases. Gross tumor volumes were higher on PET compared to MRI (*p = 0.032).
Conclusion: Our data show that [ 68 Ga]Ga-DOTA-TATE PET/CT is highly sensitive in revealing tumor remnants in patients with meningioma WHO grade 1. Negative PET findings were associated with a higher progression-free survival, thus improving surveillance. In patients with tumor remnants, additional PET can optimize adjuvant radiotherapy target planning of surgically resected meningiomas.
(© 2023. The Author(s).)
Databáze: MEDLINE
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