HIV risk behavior profiles among men who have sex with men interested in donating blood: Findings from the Assessing Donor Variability and New Concepts in Eligibility study.

Autor: Custer B; Vitalant Research Institute, San Francisco, California, USA.; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA., Whitaker BI; U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, Maryland, USA., Pollack LM; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA., Buccheri R; Vitalant Research Institute, San Francisco, California, USA.; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA., Bruhn RL; Vitalant Research Institute, San Francisco, California, USA.; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA., Crowder LA; American Red Cross, Scientific Affairs, Rockville, Maryland, USA., Stramer SL; American Red Cross, Scientific Affairs, Gaithersburg, Maryland, USA., Reik RA; OneBlood, St. Petersburg, Florida, USA., Pandey S; Stanford Blood Center & Stanford University, Palo Alto, California, USA., Stone M; Vitalant Research Institute, San Francisco, California, USA.; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA., Di Germanio C; Vitalant Research Institute, San Francisco, California, USA.; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA., Buchacz K; U.S. Centers for Disease Control and Prevention, HIV Research Branch, Division of HIV Prevention, Atlanta, Georgia, USA., Eder AF; U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, Maryland, USA., Lu Y; U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, Maryland, USA., Forshee RA; U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, Maryland, USA., Anderson SA; U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, Maryland, USA., Marks PW; U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, Maryland, USA.
Jazyk: angličtina
Zdroj: Transfusion [Transfusion] 2023 Oct; Vol. 63 (10), pp. 1872-1884. Date of Electronic Publication: 2023 Aug 29.
DOI: 10.1111/trf.17515
Abstrakt: Background: Individual risk assessment allows donors to be evaluated based on their own behaviors. Study objectives were to assess human immunodeficiency virus (HIV) risk behaviors in men who have sex with men (MSM) and estimate the proportion of the study population who would not be deferred for higher risk HIV sexual behaviors.
Study Design and Methods: Cross-sectional survey and biomarker assessment were conducted in eight U.S. cities. Participants were sexually active MSM interested in blood donation aged 18-39 years, assigned male sex at birth. Participants completed surveys during two study visits to define eligibility, and self-reported sexual and HIV prevention behaviors. Blood was drawn at study visit 1 and tested for HIV and the presence of tenofovir, one of the drugs in oral HIV pre-exposure prophylaxis (PrEP). Associations were assessed between HIV infection status or HIV PrEP use and behaviors, including sex partners, new partners, and anal sex.
Results: A total of 1566 MSM completed the visit 1 questionnaire and blood draw and 1197 completed the visit 2 questionnaire. Among 1562 persons without HIV, 789 (50.4%) were not taking PrEP. Of those not taking PrEP, 66.2% reported one sexual partner or no anal sex and 69% reported no new sexual partners or no anal sex with a new partner in the past 3 months.
Conclusion: The study found that questions were able to identify sexually active, HIV-negative MSM who report lower risk sexual behaviors. About a quarter of enrolled study participants would be potentially eligible blood donors using individual risk assessment questions.
(© 2023 AABB.)
Databáze: MEDLINE
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