Left atrial strain and ventricular global longitudinal strain in cirrhotic patients using the new criteria of Cirrhotic Cardiomyopathy Consortium.

Autor: Skouloudi M; Department of Cardiology, General Hospital of Athens 'Laiko', Athens, Greece., Bonou MS; Department of Cardiology, General Hospital of Athens 'Laiko', Athens, Greece., Adamantou M; First Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Parastatidou D; Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Kapelios C; Department of Cardiology, General Hospital of Athens 'Laiko', Athens, Greece., Masoura K; Department of Cardiology, General Hospital of Athens 'Laiko', Athens, Greece., Efstathopoulos E; 2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Aggeli C; First Department of Cardiology, General Hospital of Athens 'Hippokration', National and Kapodistrian University Athens School of Medicine, Athens, Greece., Papatheodoridis GV; Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Barbetseas J; Department of Cardiology, General Hospital of Athens 'Laiko', Athens, Greece., Cholongitas E; First Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece.
Jazyk: angličtina
Zdroj: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2023 Dec; Vol. 43 (12), pp. 2727-2742. Date of Electronic Publication: 2023 Aug 29.
DOI: 10.1111/liv.15714
Abstrakt: Background: The new criteria of Cirrhotic Cardiomyopathy Consortium (CCC) propose the use of left ventricular global longitudinal strain (LV-GLS) for evaluation of systolic function in patients with cirrhosis. The aim of this study was to evaluate LV-GLS and left atrial (LA) strain in association with the severity of liver disease and to assess the characteristics of cirrhotic cardiomyopathy (CCM).
Methods: One hundred and thirty-five cirrhotic patients were included. Standard echocardiography and speckle tracking echocardiography (2D-STE) were performed, and dual X-ray absorptiometry was used to quantify the total and regional fat mass. CCM was defined, based on the criteria of CCC, as having advanced diastolic dysfunction, left ventricular ejection fraction ≤50% and/or a GLS <18%.
Results: LV-GLS lower or higher than the absolute mean value (22.7%) was not associated with mortality (logrank, p = 0.96). LV-GLS was higher in patients with Model for end stage liver disease (MELD) score ≥15 compared to MELD score <15 (p = 0.004). MELD score was the only factor independently associated with systolic function (LV-GLS <22.7% vs. ≥22.7%) (Odds Ratio:1.141, p = 0.032). Patients with CCM (n = 11) had higher values of estimated volume of visceral adipose tissue compared with patients without CCM (median: 735 vs. 641 cm 3 , p = 0.039). On multivariable Cox regression analysis, MELD score [Hazard Ratio (HR):1.26, p < 0.001] and LA reservoir strain (HR:0.96, p = 0.017) were the only factors independently associated with the outcome.
Conclusion: In our study, absolute LV-GLS was higher in more severe liver disease, and LA reservoir strain was significantly associated with the outcome in patients with end-stage liver disease.
(© 2023 The Authors. Liver International published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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