Indications and outcomes of pediatric penetrating keratoplasty: A retrospective observational study.

Autor:	Abukahel A; Department of Ophthalmology, Jordan University Hospital, The University of Jordan, Amman, Jordan., Aldiwanie AS; Department of Ophthalmology, Jordan University Hospital, The University of Jordan, Amman, Jordan., AlRyalat SA; Department of Ophthalmology, Jordan University Hospital, The University of Jordan, Amman, Jordan., Gharaibeh AM; Department of Ophthalmology, Jordan University Hospital, The University of Jordan, Amman, Jordan.
Jazyk:	angličtina
Zdroj:	Medical hypothesis, discovery & innovation ophthalmology journal [Med Hypothesis Discov Innov Ophthalmol] 2022 Apr 01; Vol. 11 (1), pp. 27-33. Date of Electronic Publication: 2022 Apr 01 (Print Publication: 2022).
DOI:	10.51329/mehdiophthal1442
Abstrakt:	Background: Pediatric corneal transplantation can be indicated in congenital and acquired conditions. Challenges include preoperative evaluation, multiple intraoperative obstacles, and postoperative problems in follow-up and management. This study was aimed at identifying the indications and clinical outcomes of pediatric penetrating keratoplasty (PKP) in Jordan. Methods: This retrospective cohort study was conducted in Amman, Jordan. Using the hospital's electronic database, all medical records of patients aged < 18 years who underwent PKP between January 2004 and October 2019 were reviewed. Preoperative evaluations included best-corrected distance visual acuity (BCDVA) and anterior and posterior segment examinations. Postoperative complications, BCDVA, and graft survival were examined 1 year postoperatively. Results: A total of 149 cases of pediatric PKP were performed on 141 eyes of 118 patients with an age mean ± standard deviation (SD) of 11.44 ± 4.97 years at the time of surgery. Acquired non-traumatic corneal pathologies accounted for 65.8% of indications for PKP. The most frequent indication was advanced keratoconus (55.7%). Preoperative and 1-year postoperative BCDVAs significantly differed (P < 0.001), with 111 (74.5%) patients showing improved BCDVA, 12 (8.05%) patients showing worsened BCDVA, and 26 (17.45%) patients showing no change in BCDVA. The overall 1-year graft survival rate was 80.54%. Conclusions: This was the largest study in Jordan involving pediatric patients who underwent PKP for various indications, showing a significant improvement in BCDVA, with a high survival rate at 1 year. Future studies with longer follow-up periods could provide stronger evidence for surgical outcomes and graft survival. Further, the option of lamellar keratoplasty in the pediatric age group should be assessed. Competing Interests: None. (© Author(s).)
Databáze:	MEDLINE
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