A neuropathologic feature of brain aging: multi-lumen vascular profiles.

Autor: Ighodaro ET; Department of Neurology, Emory University, Atlanta, GA, USA.; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA., Shahidehpour RK; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA.; Department of Neuroscience, University of Kentucky, Lexington, KY, 40536, USA.; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, 40536, USA., Bachstetter AD; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA.; Department of Neuroscience, University of Kentucky, Lexington, KY, 40536, USA.; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, 40536, USA., Abner EL; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA.; Department of Epidemiology and Environmental Health, University of Kentucky, Lexington, KY, 40536, USA., Nelson RS; Emory University, Atlanta, GA, USA., Fardo DW; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA.; Department of Biostatistics, University of Kentucky, Lexington, KY, 40536, USA., Shih AY; Department of Pediatrics, Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, University of Washington, Seattle, WA, 98101, USA., Grant RI; Department of Neurosciences and Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, 29425, USA., Neltner JH; Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Kentucky, Lexington, KY, 40536, USA., Schmitt FA; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA.; Department of Neurology, University of Kentucky, Lexington, KY, 40536, USA., Jicha GA; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA.; Department of Neurology, University of Kentucky, Lexington, KY, 40536, USA., Kryscio RJ; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA.; Department of Statistics, University of Kentucky, Lexington, KY, 40536, USA.; Department of Biostatistics, University of Kentucky, Lexington, KY, 40536, USA., Wilcock DM; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA., Van Eldik LJ; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA.; Department of Neuroscience, University of Kentucky, Lexington, KY, 40536, USA., Nelson PT; Sanders-Brown Center On Aging, University of Kentucky, Rm 575 Lee Todd Bldg, 789 S. Limestone Ave, Lexington, KY, 40536, USA. peter.nelson@uky.edu.; Department of Neuroscience, University of Kentucky, Lexington, KY, 40536, USA. peter.nelson@uky.edu.; Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Kentucky, Lexington, KY, 40536, USA. peter.nelson@uky.edu.
Jazyk: angličtina
Zdroj: Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Aug 28; Vol. 11 (1), pp. 138. Date of Electronic Publication: 2023 Aug 28.
DOI: 10.1186/s40478-023-01638-2
Abstrakt: Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in a single vascular channel. Little information exists on the prevalence, risk factors, and co-pathologies of MVPs. Therefore, we used samples and data from the University of Kentucky Alzheimer's Disease Research Center (n = 91), the University of Kentucky Pathology Department (n = 31), and the University of Pittsburgh Pathology Department (n = 4) to study MVPs. Age at death was correlated with MVP density in the frontal neocortex, Brodmann Area 9 (r = 0.51; p < 0.0001). Exploratory analyses were performed to evaluate the association between conventional vascular risk factors (e.g., hypertension, diabetes), cardiovascular diseases (e.g., heart attack, arrhythmia), and cerebrovascular disease (e.g., stroke); the only nominal association with MVP density was a self-reported history of brain trauma (Prevalence Ratio = 2.1; 95 CI 1.1-3.9, before correcting for multiple comparisons). No specific associations were detected between neuropathological (e.g., brain arteriolosclerosis) or genetic (e.g., APOE) variables and MVP density. Using a tissue clearing method called SeeDB, we provide 3-dimensional images of MVPs in brain tissue. We conclude that MVPs are an age-related brain pathology and more work is required to identify their clinical-pathological correlation and associated risk factors.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje