Enteral L-citrulline supplementation in preterm infants is safe and effective in increasing plasma arginine and citrulline levels-a pilot randomized trial.

Autor: Qasim A; Department of Neonatology, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.; Department of Pediatrics, Section of Pediatric Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Mehdi MQ; Department of Neonatology, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.; Department of Pediatric Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Bhatia S; Department of Neonatology, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.; Division of Pediatric Cardiology, Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA., Franco-Fuenmayor ME; Department of Neonatology, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA., Jain SK; Department of Neonatology, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA. skjain@utmb.edu.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 May; Vol. 44 (5), pp. 702-708. Date of Electronic Publication: 2023 Aug 28.
DOI: 10.1038/s41372-023-01761-x
Abstrakt: Objective: Deficiencies of citrulline and arginine have been associated with adverse outcomes in preterm-infants and data regarding enteral supplementation in preterm infants is limited.
Study Design: This randomized -trial [NCT03649932] included 42 preterm infants (gestational age ≤33 weeks) randomized to receive enteral L-citrulline in low (100 mg/kg/day), medium (200 mg/kg/day) and high-dose (300 mg/kg/day) groups for 7 days. Plasma citrulline and arginine levels were obtained pre-and-post supplementation and efficacy was determined by a significant increase in levels after supplementation. A p < 0.05 was considered significant. Safety monitoring included blood-pressure-monitoring as well as complications and death during hospitalization.
Results: A total of 40/42 (95%) of the recruits completed the 7-day supplementation with no adverse events. Plasma-citrulline levels increased significantly in all three groups while plasma-arginine levels increased significantly in the high-dose group.
Conclusion: Enteral L-citrulline supplementation in preterm infants is safe and effective in increasing plasma citrulline and arginine levels.
Clinical Trial Registration: NCT03649932 https://clinicaltrials.gov/ct2/show/NCT03649932 .
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
Externí odkaz: