Neural dependency in wound healing and regeneration.

Autor: Noble A; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Qubrosi R; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Cariba S; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Favaro K; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Payne SL; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
Jazyk: angličtina
Zdroj: Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2024 Feb; Vol. 253 (2), pp. 181-203. Date of Electronic Publication: 2023 Aug 28.
DOI: 10.1002/dvdy.650
Abstrakt: In response to injury, humans and many other mammals form a fibrous scar that lacks the structure and function of the original tissue, whereas other vertebrate species can spontaneously regenerate damaged tissues and structures. Peripheral nerves have been identified as essential mediators of wound healing and regeneration in both mammalian and nonmammalian systems, interacting with the milieu of cells and biochemical signals present in the post-injury microenvironment. This review examines the diverse functions of peripheral nerves in tissue repair and regeneration, specifically during the processes of wound healing, blastema formation, and organ repair. We compare available evidence in mammalian and nonmammalian models, identifying critical nerve-mediated mechanisms for regeneration and providing future perspectives toward integrating these mechanisms into a therapeutic framework to promote regeneration.
(© 2023 The Authors. Developmental Dynamics published by Wiley Periodicals LLC on behalf of American Association for Anatomy.)
Databáze: MEDLINE
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