A review of bioanalytical applications of microextraction techniques combined with derivatization.

Autor:	Manousi N; Laboratory of Pharmaceutical Analysis, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, GR-54124, Greece., Ntorkou M; Laboratory of Pharmaceutical Analysis, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, GR-54124, Greece., Tzanavaras PD; Laboratory of Analytical Chemistry, School of Chemistry, Faculty of Sciences, Aristotle University of Thessaloniki, GR-54124, Greece., Zacharis CK; Laboratory of Pharmaceutical Analysis, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, GR-54124, Greece.
Jazyk:	angličtina
Zdroj:	Bioanalysis [Bioanalysis] 2023 Aug; Vol. 15 (15), pp. 937-954. Date of Electronic Publication: 2023 Aug 28.
DOI:	10.4155/bio-2023-0121
Abstrakt:	Microextraction techniques have attracted the attention of many researchers working in the field of bioanalysis due to their unique advantages, mainly in downsizing the scale of sample preparation steps. In parallel, analytical derivatization offers a powerful combination in terms of additional sensitivity, selectivity and compatibility with modern separation techniques. The aim of this review is to discuss the most recent advances in bioanalytical sample preparation based on the combination of microextraction and analytical derivatization. Both innovative fundamental reports and analyte-targeted applications are included and discussed. Dispersive liquid-liquid extraction and solid-phase microextraction are the most common techniques that typically combined with derivatization, while the development of novel and greener protocols is receiving substantial consideration in the field of analytical chemistry.
Databáze:	MEDLINE
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