Infection-induced seroconversion and seroprevalence of SARS-CoV-2 among a cohort of children and youth in Montreal, Canada.

Autor: Zinszer K; School of Public Health University of Montreal Montreal Quebec Canada.; Centre for Public Health Research Montreal Quebec Canada., Charland K; Centre for Public Health Research Montreal Quebec Canada., Pierce L; Centre for Public Health Research Montreal Quebec Canada., Saucier A; School of Public Health University of Montreal Montreal Quebec Canada.; Centre for Public Health Research Montreal Quebec Canada., Hamelin MÈ; Research Centre of Quebec-Université Laval Quebec City Quebec Canada., Da Torre MB; School of Public Health University of Montreal Montreal Quebec Canada.; Centre for Public Health Research Montreal Quebec Canada., Carbonneau J; Research Centre of Quebec-Université Laval Quebec City Quebec Canada., Nguyen CT; Ministère de la santé et des services sociaux Quebec City Quebec Canada., De Serres G; National Institute of Public Health of Quebec Quebec City Quebec Canada., Papenburg J; Montreal Children's Hospital of the McGill University Health Centre Montreal Quebec Canada., Boivin G; Research Centre of Quebec-Université Laval Quebec City Quebec Canada., Quach C; School of Public Health University of Montreal Montreal Quebec Canada.; Research Centre of the Sainte-Justine University Hospital Montreal Quebec Canada.
Jazyk: angličtina
Zdroj: Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2023 Aug 25; Vol. 17 (8), pp. e13186. Date of Electronic Publication: 2023 Aug 25 (Print Publication: 2023).
DOI: 10.1111/irv.13186
Abstrakt: The EnCORE study is a prospective serology study of SARS-CoV-2 in a cohort of children from Montreal, Canada. Based on data from our fourth round of data collection (May-October 2022), we estimated SARS-CoV-2 seroprevalence and seroconversion. Using multivariable regression, we identified factors associated with seroconversion. Our results show that previously seronegative children were approximately 9-12 times more likely to seroconvert during the early Omicron-dominant period compared to pre-Omicron rounds. Unlike the pre-Omicron rounds, the adjusted rate of seroconversion among 2- to 4-year-olds was higher than older age groups. As seen previously, higher seroconversion rates were associated with ethnic/racial minority status.
Competing Interests: JP reports grants from MedImmune, grants and personal fees from Merck and AbbVie, and personal fees from AstraZeneca, all outside the submitted work.
(© 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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