Prevention of Uterine Fibroids: molecular mechanisms and potential clinical application.

Autor:	Ali M; Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA Chicago, IL 60637, USA.; Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Bariani MV; Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA Chicago, IL 60637, USA., Vafaei S; Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA Chicago, IL 60637, USA., Omran MM; Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA Chicago, IL 60637, USA.; Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt., Yang Q; Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA Chicago, IL 60637, USA., Madueke-Laveaux OS; Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA Chicago, IL 60637, USA., Al-Hendy A; Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA Chicago, IL 60637, USA.
Jazyk:	angličtina
Zdroj:	Journal of endometriosis and uterine disorders [J Endometr Uterine Disord] 2023 Mar; Vol. 1. Date of Electronic Publication: 2023 Feb 15.
DOI:	10.1016/j.jeud.2023.100018
Abstrakt:	Uterine fibroids (UFs; leiomyoma) are the most common benign neoplastic threat to women worldwide, exacting an immense personal burden on female health and a monetary expense to the healthcare system estimated in the hundreds of billions of dollars every year globally. With no long-term non-invasive treatment option currently available to treat UFs, deeper insights regarding tumor etiology are the key for developing newer therapies. Accordingly, in this review, we discuss new mechanistic paradigm to explain UF tumor development through an exquisite model involving developmental reprogramming of myometrial stem cells due to early life endocrine disruptors exposure, inflammation, fibrosis, DNA damage, and eventually tissue stiffness. Further, we propose to utilize shear wave elastography as a potential screening tool for the early identification of women at risk for developing UFs who can benefit from several simple preventive strategies, including the consumption of natural compounds such as vitamin D and green tea as a safe fertility friendly non-hormonal modality to delay or even arrest or reverse UF progression. Competing Interests: Conflict of interest: The authors declare that they have no conflict of interest. Ayman Al-Hendy reports was provided by National Institutes of Health. Ayman Al-Hendy reports a relationship with Myovant Sciences Ltd and Pfizer that includes: consulting or advisory. Corresponding author: Dr. Ayman Al-Hendy is the founder of INOFFA company.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu