Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls.
| Autor: | Tahery N; Nursing Faculty, Abadan University of Medical Sciences, Abadan, Iran., Rezaei Tavirani M; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Zamanian Azodi M; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Hamdieh M; Psychosomatic Department, Taleghani Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Rostami Nejad M; Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mahmoodi N; Nursing Faculty, Abadan University of Medical Sciences, Abadan, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Iranian journal of child neurology [Iran J Child Neurol] 2023 Summer; Vol. 17 (3), pp. 133-142. Date of Electronic Publication: 2023 Jul 01. |
| DOI: | 10.22037/ijcn.v17i1.34795 |
| Abstrakt: | Objectives: The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls. Materials & Methods: Serum proteome of women with OCD/BP, pure OCD individuals, and healthy controls were subjected to 2DE-based proteomics accompanied with MALDI-TOF-TOF mass spectrometry. Further evaluation of the identified protein spots with the significance of p<0.05 and fold≥1.5 was done by applying protein interaction mapping via Cytoscape v. 5.3.1 and its plugins. Results: The results indicate that vitamin D binding protein (GC) and haptoglobin spots (HP) significantly changed expression in OCD and OCD/BP with different expression patterns. These identified spots may contribute to OCD/BP and act as differentially recognized biomarkers comparing pure OCD and OCD/BP. Conclusion: The Findings imply that these proteins in the serum of the patients could be potential distinguishable biomarkers in clinical usage after related validation experiments. Therefore, this study provides a preliminary evaluation to understand OCD/BP proteome behavior better. Competing Interests: None |
| Databáze: | MEDLINE |
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