Application of Metal-Organic Frameworks for Efficient Removal of Doxorubicin Hydrochloride: Removal Process Optimization and Biological Activity.

Autor:	Alkhamis KM; Department of Chemistry, College of Science, University of Tabuk, Tabuk 71474, Saudi Arabia., Aljohani MM; Department of Chemistry, College of Science, University of Tabuk, Tabuk 71474, Saudi Arabia., Ibarhiam SF; Department of Chemistry, College of Science, University of Tabuk, Tabuk 71474, Saudi Arabia., Hameed YAS; Department of Chemistry, Faculty of Science, Northern Border University, Arar 73222, Saudi Arabia., Abumelha HM; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Habeebullah TM; Department of Environment and Health Research, The Custodian of Two Holy Mosques Institute for Hajj and Umrah Research, Umm Al-Qura University, Makkah 21955, Saudi Arabia., El-Metwaly NM; Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.; Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2023 Aug 08; Vol. 8 (33), pp. 30374-30388. Date of Electronic Publication: 2023 Aug 08 (Print Publication: 2023).
DOI:	10.1021/acsomega.3c03523
Abstrakt:	This study looked at the doxorubicin hydrochloride (DOX) anticancer drug's adsorption characteristics on a silver-based metal-organic framework (Ag-MOF). X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) were used for the characterization of Ag-MOF. The pore volume and surface area of Ag-MOF were determined through Brunauer-Emmett-Teller (BET) testing at 77 K to be 0.509 cm 3 /g and 676.059 m 2 /g, respectively. Adsorption at pH 6 was established to be the best for DOX compared to alkaline solution. Ag-MOF has a good capacity for eliminating DOX (1.85 mmol/g), according to adsorption experiments. From the adsorption results, we can find that Langmuir is the most fitted adsorption isotherm model and the pseudo-second order model best fitted the adsorption kinetics. The energy of activation for adsorption, which was determined to be 15.23 kJ/mol, also supported a chemisorption process. The mechanism of adsorption was evaluated, and details of all possible interactions between DOX and Ag-MOF were illustrated. On the other hand, while examining the impact of temperature, we identified the thermodynamic constraints as Δ G °, Δ H °, and Δ S ° and confirmed that the reaction was an endothermic one and spontaneous. Even after numerous reuse cycles, the efficiency remained constant. The synthetic adsorbent was remarkably recyclable at a rate of more than 91.6%. By using the MTT assay, the cytotoxicity of the tested Ag-MOF and DOX@Ag-MOF against human breast cancer cells (MCF-7) was evaluated in vitro . The in vitro antimicrobial activity of Ag-MOF and DOX@Ag-MOF was also tested. Competing Interests: The authors declare no competing financial interest. (© 2023 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu