Associations between serum taurine concentrations in mothers and neonates and the children's anthropometrics and early neurodevelopment: Results from the Seychelles Child Development Study, Nutrition Cohort 2.

Autor: Beggan LA; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, UK., Mulhern MS; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, UK. Electronic address: m.mulhern@ulster.ac.uk., Mæhre HK; Norwegian College of Fishery Science, UIT The Arctic University of Norway, Tromsø, Norway., McSorley EM; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, UK., Yeates AJ; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, UK., Zavez A; School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA., Thurston SW; School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA., Shamlaye C; Ministry of Health, Mahé, Republic of Seychelles, Seychelles., van Wijngaarden E; School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA., Davidson PW; School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA., Myers GJ; School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA., Strain JJ; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, UK., Elvevoll EO; Norwegian College of Fishery Science, UIT The Arctic University of Norway, Tromsø, Norway.
Jazyk: angličtina
Zdroj: Neurotoxicology [Neurotoxicology] 2023 Dec; Vol. 99, pp. 43-49. Date of Electronic Publication: 2023 Aug 25.
DOI: 10.1016/j.neuro.2023.08.004
Abstrakt: Background: High concentrations of taurine are present in the developing human brain and maternal breast milk. Taurine is thought to influence fetal growth and brain development based on experimental rodent studies. As fish is an important dietary source of taurine, we investigated associations between taurine concentrations and child outcomes in a high fish consuming population.
Objective: To examine associations between maternal and cord serum taurine concentrations and birth anthropometric measures and cognitive development in children at 20 months of age.
Methods: Pregnant women were recruited between 2008 and 2011 as part of Nutrition Cohort 2 (NC2) of the Seychelles Child Development Study (SCDS). Maternal taurine serum concentrations were measured at 28 week's gestation and in cord serum. Child weight, length and head circumference were measured at birth and neurodevelopment was assessed using Bayley Scales of Infant Development II (BSID-II) at 20 months of age. Associations between taurine status, birth measures and neurodevelopmental outcomes were examined (n = 300) using regression models and adjusted for relevant covariates.
Results: Mean (SD) maternal and cord taurine concentrations were 124.9 (39.2) µmol/L (range 28.2-253.9 µmol/L) and 187.6 (60.0) µmol/L (range 55.0-417.4 µmol/L) respectively. We found no associations between maternal taurine concentrations and child anthropometric and neurodevelopmental measures (weight β = -0.001, SE=0.001; length β = -0.006, SE=0.006; head circumference β = -0.002, SE=0.002; MDI β = -0.005, SE=0.015; PDI β = -0.004, SE=0.016; all P > 0.05), or between cord taurine concentrations and outcomes (weight β = -0.001, SE<0.000; length β = -0.001, SE=0.004; head circumference β < 0.000, SE=0.002; MDI β = 0.004, SE=0.010; PDI β = -0.015, SE=0.012; all P > 0.05).
Conclusion: The Seychellois population have high maternal and cord taurine concentrations owing to their high fish intake and may be considered taurine replete compared to individuals who consume a Westernised diet. This high taurine status may explain why there were no significant associations between maternal and cord taurine concentrations and outcomes after adjusting for covariates.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Conflict of Interest No conflict of interest.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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