Genetics and epigenetics of human aggression.

Autor:	Odintsova VV; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands; Mental Health Division, Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands., Hagenbeek FA; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Mental Health Division, Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands., van der Laan CM; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Netherlands Institute for the Study of Crime and Law Enforcement (NSCR), Amsterdam, The Netherlands., van de Weijer S; Netherlands Institute for the Study of Crime and Law Enforcement (NSCR), Amsterdam, The Netherlands., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands. Electronic address: di.boomsma@vu.nl.
Jazyk:	angličtina
Zdroj:	Handbook of clinical neurology [Handb Clin Neurol] 2023; Vol. 197, pp. 13-44.
DOI:	10.1016/B978-0-12-821375-9.00005-0
Abstrakt:	There is substantial variation between humans in aggressive behavior, with its biological etiology and molecular genetic basis mostly unknown. This review chapter offers an overview of genomic and omics studies revealing the genetic contribution to aggression and first insights into associations with epigenetic and other omics (e.g., metabolomics) profiles. We allowed for a broad phenotype definition including studies on "aggression," "aggressive behavior," or "aggression-related traits," "antisocial behavior," "conduct disorder," and "oppositional defiant disorder." Heritability estimates based on family and twin studies in children and adults of this broadly defined phenotype of aggression are around 50%, with relatively small fluctuations around this estimate. Next, we review the genome-wide association studies (GWAS) which search for associations with alleles and also allow for gene-based tests and epigenome-wide association studies (EWAS) which seek to identify associations with differently methylated regions across the genome. Both GWAS and EWAS allow for construction of Polygenic and DNA methylation scores at an individual level. Currently, these predict a small percentage of variance in aggression. We expect that increases in sample size will lead to additional discoveries in GWAS and EWAS, and that multiomics approaches will lead to a more comprehensive understanding of the molecular underpinnings of aggression. (Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu