Quantitative proteomic profile analysis of thyroid dysfunction effects on seminal vesicles and repercussions on male fertility.

Autor: Corrêa DEDC; Department of Medicine, State University of Central-West (UNICENTRO), Guarapuava, Parana, Brazil., Bargi-Souza P; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Oliveira IM; Department of Medicine, State University of Central-West (UNICENTRO), Guarapuava, Parana, Brazil., Razera A; Department of Medicine, State University of Central-West (UNICENTRO), Guarapuava, Parana, Brazil., Oliveira CA; Department of Animal Reproduction, Faculty of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil., Romano MA; Department of Medicine, State University of Central-West (UNICENTRO), Guarapuava, Parana, Brazil., Romano RM; Department of Medicine, State University of Central-West (UNICENTRO), Guarapuava, Parana, Brazil. Electronic address: romano@unicentro.br.
Jazyk: angličtina
Zdroj: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2023 Dec 01; Vol. 578, pp. 112048. Date of Electronic Publication: 2023 Aug 25.
DOI: 10.1016/j.mce.2023.112048
Abstrakt: Hypothyroidism and thyrotoxicosis are associated with male reproductive disorders, but little is known about the influence of the thyroid hormone milieu on seminal vesicle (SV) function and metabolism. In this sense, we investigated the effects of hypothyroidism and thyrotoxicosis induced in adulthood Wistar male rats on SV function and identified new thyroid hormone targets on male reproduction regulation using novel proteomic approaches. Hypothyroidism reduces SV size and seminal fluid volume, which are directly associated with low testosterone and estradiol levels, while thyrotoxicosis increases Esr2 and Dio1 expression in the SV. We found 116 differentially expressed proteins. Hypothyroidism reduces the expression of molecular protein markers related to sperm viability, capacitation and fertilization, protection against oxidative stress and energetic metabolism in SV, while it increases the expression of proteins related to tissue damage. In conclusion, thyroid dysfunction in the adult phase impairs several morphological, molecular and functional characteristics of SV.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: