Evaluation of T-cell subsets in pregnant women infected with SARS-CoV-2.

Autor: Kulhan M; Selcuk University Medical Faculty, Gynaecology and Obstetrics Department, Konya, Turkey. Electronic address: mehmet_kulhan@yahoo.com., Ozdemir H; Selcuk University Medical Faculty, Medical Biology Department, Konya, Turkey. Electronic address: hulyaozdemir1@gmail.com., Bilgi A; Selcuk University Medical Faculty, Gynaecology and Obstetrics Department, Konya, Turkey. Electronic address: abilgi77@gmail.com., Celik C; Selcuk University Medical Faculty, Gynaecology and Obstetrics Department, Konya, Turkey. Electronic address: celikcet@hotmail.com., Aktug Demir N; Selcuk University Medical Faculty, Infectious Diseases and Clinical Microbiology Department, Konya, Turkey. Electronic address: naktugdemir@yahoo.com., Turk Dagi H; Selcuk University Medical Faculty, Microbiology Department, Konya, Turkey. Electronic address: haticeturkdagi@yahoo.com., Ucar MG; Selcuk University Medical Faculty, Gynaecology and Obstetrics Department, Konya, Turkey. Electronic address: mustafa_gazi_ucar@hotmail.com., Kulhan NG; Konya Education Research Hospital, Gynaecology and Obstetrics Department, Konya, Turkey. Electronic address: gozdemirel1@hotmail.com., Artac H; Selcuk University Medical Faculty, Child Health and Diseases Department, Konya, Turkey. Electronic address: hasibeartac@yahoo.com.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2023 Nov; Vol. 124 (Pt A), pp. 110798. Date of Electronic Publication: 2023 Aug 24.
DOI: 10.1016/j.intimp.2023.110798
Abstrakt: Objective: Immune responses to SARS-CoV-2 are the main cause of tissue damage in coronavirus disease 2019. However, the pathophysiological mechanism of the disease has not been fully elucidated. The aim of this study was to examine T cell subsets of pregnant women infected with SARS-CoV-2 and evaluate the relationship between the possible differences in trimesters and clinical findings of the disease.
Materials and Methods: Fifty-six pregnant patients with SARS-CoV-2 and 61 healthy pregnant controls were included in the study. T cell subsets were analyzed by flow cytometry.
Results: The CD3 + total T cell (p = 0.006 and p = 0.027) of pregnant patients infected with SARS-CoV-2 in second and third trimesters was found to be lower than in the control group. CD3 + CD4 + helper T cell (p = 0.035), Treg (p = 0.001), and Treg/Th17 ratio (p = 0.001) were found to be lower in the third trimester patients infected with SARS-CoV-2 than in the controls. Significant decreases were observed only in the Treg (p = 0.001) and Treg/Th17 ratio (p = 0.001) in the first trimester patients infected with SARS-CoV-2 compared to the controls. When trimesters were compared in terms of T subsets, no difference was found (p > 0.05).
Conclusion: The CD3 + total T cell (p = 0.001), CD3 + CD4 + helper T cell (p = 0.011), Treg (p = 0.001), and Treg/Th17 ratio (p = 0.001) were found to be lower in pregnant women infected with SARS-CoV-2. This difference was associated with the development of pneumonia but not with adverse pregnancy outcomes.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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