q21.21 characterized by array CGH in a 131/2-year-old girl with short stature, mental retardation, developmental delay, hyperopia, exotropia, enamel defects, delayed tooth eruption and delayed puberty. Genetic Counseling, 22(3), 255-261.
Cheng, H., Dharmadhikari, A. V., Varland, S., Ma, N., Domingo, D., Kleyner, R., Rope, A. F., Yoon, M., Stray-Pedersen, A., Posey, J. E., Crews, S. R., Eldomery, M. K., Akdemir, Z. C., Lewis, A. M., Sutton, V. R., Rosenfeld, J. A., Conboy, E., Agre, K., Xia, F., … Lyon, G. J. (2018). Truncating variants in NAA15 are associated with variable levels of intellectual disability, autism spectrum disorder, and congenital anomalies. American Journal of Human Genetics, 102(5), 985-994. https://doi.org/10.1016/j.ajhg.2018.03.004.
Chew, E., Remaley, N. A., Tamboli, A., Zhao, J., Podgor, M. J., & Klebanoff, M. (1994). Risk factors for esotropia and exotropia. Archives of Ophthalmology, 112(10), 1349-1355. https://doi.org/10.1001/archopht.1994.01090220099030.
Chien, Y. L., Gau, S. F., Chiu, Y. N., Tsai, W. C., Shang, C. Y., & Wu, Y. Y. (2014). Impaired sustained attention, focused attention, and vigilance in youths with autistic disorder and Asperger's disorder as compared to typically developing youths. Research in Autism Spectrum Disorder, 8(7), 881-889.
Chien, Y. L., Wu, C. S., & Tsai, H. J. (2021). The comorbidity of schizophrenia Spectrum and mood disorders in autism spectrum disorder. Autism Research, 14(3), 571-581. https://doi.org/10.1002/aur.2451.
Constantino, J. N., Zhang, Y., Frazier, T., Abbacchi, A. M., & Law, P. (2010). Sibling recurrence and the genetic epidemiology of autism. The American Journal of Psychiatry, 167(11), 1349-1356. https://doi.org/10.1176/appi.ajp.2010.09101470.
Das, M., Spowart, K., Crossley, S., & Dutton, G. N. (2010). Evidence that children with special needs all require visual assessment. Archives of Disease in Childhood, 95(11), 888-892. https://doi.org/10.1136/adc.2009.159053.
De Rubeis, S., He, X., Goldberg, A. P., Poultney, C. S., Samocha, K., Cicek, A. E., Kou, Y., Liu, L., Fromer, M., Walker, S., Singh, T., Klei, L., Kosmicki, J., Shih-Chen, F., Aleksic, B., Biscaldi, M., Bolton, P. F., Brownfeld, J. M., Cai, J., … Buxbaum, J. D. (2014). Synaptic, transcriptional and chromatin genes disrupted in autism. Nature, 515(7526), 209-215. https://doi.org/10.1038/nature13772.
Denis, D., Burillon, C., Livet, M. O., & Burguiere, O. (1997). Ophthalmologic signs in children with autism. Journal Français d'Ophtalmologie, 20(2), 103-110.
Di Napoli, A., Warrier, V., Baron-Cohen, S., & Chakrabarti, B. (2015). Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger syndrome. Molecular Autism, 6, 9. https://doi.org/10.1186/s13229-015-0009-0.
Dong, S., Walker, M. F., Carriero, N. J., DiCola, M., Willsey, A. J., Ye, A. Y., Waqar, Z., Gonzalez, L. E., Overton, J. D., Frahm, S., Keaney, J. F., Teran, N. A., Dea, J., Mandell, J. D., Bal, V. H., Sullivan, C. A., DiLullo, N. M., Khalil, R. O., Gockley, J., … Sanders, S. J. (2014). De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder. Cell Reports, 9(1), 16-23. https://doi.org/10.1016/j.celrep.2014.08.068.
Dufier, J. L., Briard, M. L., Bonaiti, C., Frezal, J., & Saraux, H. (1979). Inheritance in the etiology of convergent squint. Ophthalmologica, 179(4), 225-234. https://doi.org/10.1159/000308899.
Dunn, K., Rydzewska, E., Fleming, M., & Cooper, S.-A. (2020). Prevalence of mental health conditions, sensory impairments and physical disability in people with co-occurring intellectual disabilities and autism compared with other people: A cross-sectional total population study in Scotland. BMJ Open, 10(4), e035280. https://doi.org/10.1136/bmjopen-2019-035280.
Elsabbagh, M., Divan, G., Koh, Y. J., Kim, Y. S., Kauchali, S., Marcín, C., Garcia, R., Rosoli, A., Valdez, D., Bordini, D., Shih, A., Garrido, G., & Fombonne, E. (2012). Global prevalence of autism and other pervasive developmental disorders. Autism Research, 5(3), 160-179. https://doi.org/10.1002/aur.239.
Engle, E. C. (2007). Genetic basis of congenital strabismus. Archives of Ophthalmology, 125(2), 189-195. https://doi.org/10.1001/archopht.125.2.189.
Evenhuis, H. M. (1995). Medical aspects of ageing in a population with intellectual disability: I. visual impairment. Journal of Intellectual Disability Research, 39(Pt 1), 19-25.
Fombonne, E. (2009). Epidemiology of pervasive developmental disorders. Pediatric Research, 65(6), 591-598. https://doi.org/10.1203/PDR.0b013e31819e7203.
Grønborg, T. K., Schendel, D. E., & Parner, E. T. (2013). Recurrence of autism spectrum disorders in full- and half-siblings and trends over time: A population-based cohort study. JAMA Pediatrics, 167(10), 947-953. https://doi.org/10.1001/jamapediatrics.2013.2259.
Grove, J., Ripke, S., Als, T. D., Mattheisen, M., Walters, R. K., Won, H., Pallesen, J., Agerbo, E., Andreassen, O. A., Anney, R., Awashti, S., Belliveau, R., Bettella, F., Buxbaum, J. D., Bybjerg-Grauholm, J., Baekvad-Hansen, M., Cerrato, F., Chambert, K., Christensen, J. H., … Børglum, A. D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51(3), 431-444. https://doi.org/10.1038/s41588-019-0344-8.
Guissart, C., Latypova, X., Rollier, P., Khan, T. N., Stamberger, H., McWalter, K., Cho, M. T., Kjaergaard, S., Weckhuysen, S., Lesca, G., Besnard, T., Õunap, K., Schema, L., Chiocchetti, A. G., McDonald, M., de Bellescize, J., Vincent, M., Van Esch, H., Sattler, S., … Küry, S. (2018). Dual molecular effects of dominant RORA mutations cause two variants of syndromic intellectual disability with either autism or cerebellar ataxia. American Journal of Human Genetics, 102(5), 744-759. https://doi.org/10.1016/j.ajhg.2018.02.021.
Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., Miller, J., Fedele, A., Collins, J., Smith, K., Lotspeich, L., Croen, L. A., Ozonoff, S., Lajonchere, C., Grether, J. K., & Risch, N. (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of General Psychiatry, 68(11), 1095-1102. https://doi.org/10.1001/archgenpsychiatry.2011.76.
Horta-Santini, J. M., Vergara, C., Colón-Casasnovas, J. E., & Izquierdo, N. J. (2011). Strabismus surgery at the Puerto Rico medical center: A brief report. Puerto Rico Health Sciences Journal, 30(4), 203-205.
Ibironke, J. O., Friedman, D. S., Repka, M. X., Katz, J., Giordano, L., Hawse, P., & Tielsch, J. M. (2011). Child development and refractive errors in preschool children. Optometry and Vision Science, 88(2), 181-187. https://doi.org/10.1097/OPX.0b013e318204509b.
Ikeda, J., Davitt, B. V., Ultmann, M., Maxim, R., & Cruz, O. A. (2013). Brief report: Incidence of ophthalmologic disorders in children with autism. Journal of Autism and Developmental Disorders, 43(6), 1447-1451. https://doi.org/10.1007/s10803-012-1475-2.
Iossifov, I., O'Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., Smith, J. D., Paeper, B., Nickerson, D. A., Dea, J., Dong, S., Gonzalez, L. E., Mandell, J. D., Mane, S. M., Murtha, M. T., … Wigler, M. (2014). The contribution of de novo coding mutations to autism spectrum disorder. Nature, 515(7526), 216-221. https://doi.org/10.1038/nature13908.
Jacquemont, S., Coe, B. P., Hersch, M., Duyzend, M. H., Krumm, N., Bergmann, S., Beckmann, J. S., Rosenfeld, J. A., & Eichler, E. E. (2014). A higher mutational burden in females supports a “female protective model” in neurodevelopmental disorders. American Journal of Human Genetics, 94(3), 415-425. https://doi.org/10.1016/j.ajhg.2014.02.001.
Kabatas, E. U., Ozer, P. A., Ertugrul, G. T., Kurtul, B. E., Bodur, S., & Alan, B. E. (2015). Initial ophthalmic findings in Turkish children with autism Spectrum disorder. Journal of Autism and Developmental Disorders, 45(8), 2578-2581. https://doi.org/10.1007/s10803-015-2428-3.
Krämer, J., Beer, M., Bode, H., & Winter, B. (2021). Two novel compound heterozygous mutations in the TRAPPC9 gene reveal a connection of non-syndromic intellectual disability and autism spectrum disorder. Frontiers in Genetics, 11, 972. https://doi.org/10.3389/fgene.2020.00972.
Kuhn, G., Benson, V., Fletcher-Watson, S., Kovshoff, H., McCormick, C. A., Kirkby, J., & Leekam, S. R. (2010). Eye movements affirm: Automatic overt gaze and arrow cueing for typical adults and adults with autism spectrum disorder. Experimental Brain Research, 201(2), 155-165. https://doi.org/10.1007/s00221-009-2019-7.
Lai, M. C., Lombardo, M. V., Auyeung, B., Chakrabarti, B., & Baron-Cohen, S. (2015). Sex/gender differences and autism: Setting the scene for future research. Journal of the American Academy of Child and Adolescent Psychiatry, 54(1), 11-24. https://doi.org/10.1016/j.jaac.2014.10.003.
Li, J., Wong, K., Park, A. S., Fricke, T. R., & Jackson, A. J. (2015). The challenges of providing eye care for adults with intellectual disabilities. Clinical & Experimental Optometry, 98(5), 420-429. https://doi.org/10.1111/cxo.12304.
Liu, C.-Y., Hung, Y.-T., Chuang, Y.-L., Chen, Y.-J., Weng, W.-S., Liu, J.-S., & Liang, K. (2006). Incorporating development stratification of Taiwan townships into sampling design of large scale health interview survey. Journal of Health Management, 4(1), 1-22.
Maconachie, G. D., Gottlob, I., & McLean, R. J. (2013). Risk factors and genetics in common comitant strabismus: A systematic review of the literature. JAMA Ophthalmology, 131(9), 1179-1186. https://doi.org/10.1001/jamaophthalmol.2013.4001.
Maenner, M. J., Shaw, K. A., Baio, J., Washington, A., Patrick, M., DiRienzo, M., Christensen, D. L., Wiggins, L. D., Pettygrove, S., Andrews, J. G., Lopez, M., Hudson, A., Baroud, T., Schwenk, Y., White, T., Rosenberg, C. R., Lee, L. C., Harrington, R. A., Huston, M., … Dietz, P. M. (2020). Prevalence of autism spectrum disorder among children aged 8 years: autism and developmental disabilities monitoring network, 11 sites, United States, 2016. MMWR Surveillance Summaries, 69(4), 1-12. https://doi.org/10.15585/mmwr.ss6904a1.
Mash, A. J., & Spivey, B. E. (1973). Genetic aspects of strabismus. Documenta Ophthalmologica, 34(1), 285-291. https://doi.org/10.1007/bf00151815.
McBride, G. R., Stephenson, K. A. J., Comer, G., & Flanagan, O. (2021). The use of oral midazolam to facilitate the ophthalmic examination of children with autism and developmental disorders. Journal of Autism and Developmental Disorders, 51(5), 1678-1682. https://doi.org/10.1007/s10803-020-04658-2.
Michieletto, P., Bonanni, P., & Pensiero, S. (2011). Ophthalmic findings in Angelman syndrome. Journal of AAPOS, 15(2), 158-161. https://doi.org/10.1016/j.jaapos.2010.12.013.
Milne, E., Griffiths, H., Buckley, D., & Scope, A. (2009). Vision in children and adolescents with autistic spectrum disorder: Evidence for reduced convergence. Journal of Autism and Developmental Disorders, 39(7), 965-975. https://doi.org/10.1007/s10803-009-0705-8.
Montgomery, C. B., Allison, C., Lai, M. C., Cassidy, S., Langdon, P. E., & Baron-Cohen, S. (2016). Do adults with high functioning autism or Asperger syndrome differ in empathy and emotion recognition? Journal of Autism and Developmental Disorders, 46(6), 1931-1940. https://doi.org/10.1007/s10803-016-2698-4.
Nusz, K. J., Mohney, B. G., & Diehl, N. N. (2005). Female predominance in intermittent exotropia. American Journal of Ophthalmology, 140(3), 546-547. https://doi.org/10.1016/j.ajo.2005.03.026.
O'Connor, A. R., Stephenson, T. J., Johnson, A., Tobin, M. J., Ratib, S., & Fielder, A. R. (2002). Strabismus in children of birth weight less than 1701 g. Archives of Ophthalmology, 120(6), 767-773. https://jamanetwork.com/journals/jamaophthalmology/articlepdf/270986/eeb10006.pdf.
Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., Bryson, S., Carver, L. J., Constantino, J. N., Dobkins, K., Hutman, T., Iverson, J. M., Landa, R., Rogers, S. J., Sigman, M., & Stone, W. L. (2011). Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics, 128(3), e488-e495. https://doi.org/10.1542/peds.2010-2825.
Parenti, I., Lehalle, D., Nava, C., Torti, E., Leitão, E., Person, R., Mizuguchi, T., Matsumoto, N., Kato, M., Nakamura, K., de Man, S. A., Cope, H., Shashi, V., Undiagnosed Diseases Network, Friedman, J., Joset, P., Steindl, K., Rauch, A., Muffels, I., … Mignot, C. (2021). Missense and truncating variants in CHD5 in a dominant neurodevelopmental disorder with intellectual disability, behavioral disturbances, and epilepsy. Human Genetics, 140(7), 1109-1120. https://doi.org/10.1007/s00439-021-02283-2.
Parmar, K. R., Porter, C. S., Dickinson, C. M., Baimbridge, P., Pelham, J., & Gowen, E. (2022). Autism-friendly eyecare: Developing recommendations for service providers based on the experiences of autistic adults. Ophthalmic & Physiological Optics, 42(4), 675-693. https://doi.org/10.1111/opo.12975.
Phillips, P. H., Fray, K. J., & Brodsky, M. C. (2005). Intermittent exotropia increasing with near fixation: A “soft” sign of neurological disease. British Journal of Ophthalmology, 89(9), 1120-1122. https://doi.org/10.1136/bjo.2004.063123.
Reynolds, M., Faron, N.,. J., Hoekel, J., & Tychsen, L. (2021). Excimer laser keratectomy and phakic intraocular lens implantation surgery for children with autism: Improvements in visual function and behavior. Journal of American Association for Pediatric Ophthalmology and Strabismus, 25(4), e9. https://doi.org/10.1016/j.jaapos.2021.08.037.
Robinson, E. B., Lichtenstein, P., Anckarsäter, H., Happé, F., & Ronald, A. (2013). Examining and interpreting the female protective effect against autistic behavior. Proceedings of the National Academy of Sciences of the United States of America, 110(13), 5258-5262. https://doi.org/10.1073/pnas.1211070110.
Rosenberg, R. E., Law, J. K., Yenokyan, G., McGready, J., Kaufmann, W. E., & Law, P. A. (2009). Characteristics and concordance of autism spectrum disorders among 277 twin pairs. Archives of Pediatrics & Adolescent Medicine, 163(10), 907-914. https://doi.org/10.1001/archpediatrics.2009.98.
Salt, A., & Sargent, J. (2014). Common visual problems in children with disability. Archives of Disease in Childhood, 99(12), 1163-1168. https://doi.org/10.1136/archdischild-2013-305267.
Sanders, S. J., Murtha, M. T., Gupta, A. R., Murdoch, J. D., Raubeson, M. J., Willsey, A. J., Ercan-Sencicek, A. G., DiLullo, N. M., Parikshak, N. N., Stein, J. L., Walker, M. F., Ober, G. T., Teran, N. A., Song, Y., El-Fishawy, P., Murtha, R. C., Choi, M., Overton, J. D., Bjornson, R. D., … State, M. W. (2012). De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature, 485(7397), 237-241. https://doi.org/10.1038/nature10945.
Sandfeld Nielsen, L., Skov, L., & Jensen, H. (2007). Visual dysfunctions and ocular disorders in children with developmental delay. II. Aspects of refractive errors, strabismus and contrast sensitivity. Acta Ophthalmologica Scandinavica, 85(4), 419-426. https://doi.org/10.1111/j.1600-0420.2007.00881.x.
Sandin, S., Lichtenstein, P., Kuja-Halkola, R., Larsson, H., Hultman, C. M., & Reichenberg, A. (2014). The familial risk of autism. JAMA, 311(17), 1770-1777. https://doi.org/10.1001/jama.2014.4144.
Saunier, C., Støve, S. I., Popp, B., Gérard, B., Blenski, M., AhMew, N., de Bie, C., Goldenberg, P., Isidor, B., Keren, B., Leheup, B., Lampert, L., Mignot, C., Tezcan, K., Mancini, G. M., Nava, C., Wasserstein, M., Bruel, A. L., Thevenon, J., … Zweier, C. (2016). Expanding the phenotype associated with NAA10-related N-terminal acetylation deficiency. Human Mutation, 37(8), 755-764. https://doi.org/10.1002/humu.23001.
Scharre, J. E., & Creedon, M. P. (1992). Assessment of visual function in autistic children. Optometry and Vision Science, 69(6), 433-439.
Schneider, B. B., & Maino, D. M. (1993). Angelman syndrome. Journal of the American Optometric Association, 64(7), 502-506.
Shih, Y. F., Hsiao, C. K., Tung, Y. L., Lin, L. L., Chen, C. J., & Hung, P. T. (2004). The prevalence of astigmatism in Taiwan schoolchildren. Optometry and Vision Science, 81(2), 94-98. https://doi.org/10.1097/00006324-200402000-00007.
Spencer, M., Takahashi, N., Chakraborty, S., Miles, J., & Shyu, C. R. (2018). Heritable genotype contrast mining reveals novel gene associations specific to autism subgroups. Journal of Biomedical Informatics, 77, 50-61. https://doi.org/10.1016/j.jbi.2017.11.016.
Stephen, E., Dickson, J., Kindley, A. D., Scott, C. C., & Charleton, P. M. (2007). Surveillance of vision and ocular disorders in children with Down syndrome. Developmental Medicine and Child Neurology, 49(7), 513-515. https://doi.org/10.1111/j.1469-8749.2007.00513.x.
Su, C. C., Tsai, C. Y., Tsai, T. H., & Tsai, I. J. (2019). Incidence and risk of attention-deficit hyperactivity disorder in children with amblyopia: A nationwide cohort study. Clinical & Experimental Ophthalmology, 47(2), 259-264. https://doi.org/10.1111/ceo.13465.
Tavassoli, T., Latham, K., Bach, M., Dakin, S. C., & Baron-Cohen, S. (2011). Psychophysical measures of visual acuity in autism spectrum conditions. Vision Research, 51(15), 1778-1780. https://doi.org/10.1016/j.visres.2011.06.004.
Taylor, B., Jick, H., & Maclaughlin, D. (2013). Prevalence and incidence rates of autism in the UK: Time trend from 2004-2010 in children aged 8 years. BMJ Open, 3(10), e003219. https://doi.org/10.1136/bmjopen-2013-003219.
Trikalinos, T. A., Karvouni, A., Zintzaras, E., Ylisaukko-oja, T., Peltonen, L., Järvelä, I., & Ioannidis, J. P. (2006). A heterogeneity-based genome search meta-analysis for autism-spectrum disorders. Molecular Psychiatry, 11(1), 29-36. https://doi.org/10.1038/sj.mp.4001750.
Tsai, L. Y., & Ghaziuddin, M. (2014). DSM-5 ASD moves forward into the past. Journal of Autism and Developmental Disorders, 44(2), 321-330. https://doi.org/10.1007/s10803-013-1870-3.
Tsai, T. H., Liu, Y. L., Ma, I. H., Su, C. C., Lin, C. W., Lin, L. L., Lin, L. L.-K., Hsiao, C. K., & Wang, I. J. (2021). Evolution of the prevalence of myopia among Taiwanese school children: A review of survey data from 1983 through 2017. Ophthalmology, 128(2), 290-301. https://doi.org/10.1016/j.ophtha.2020.07.017.
van den Broek, E. G., Janssen, C. G., van Ramshorst, T., & Deen, L. (2006). Visual impairments in people with severe and profound multiple disabilities: An inventory of visual functioning. Journal of Intellectual Disability Research, 50(Pt 6), 470-475. https://doi.org/10.1111/j.1365-2788.2006.00804.x.
Van Dijck, A., Vandeweyer, G., & Kooy, F. (1993). ADNP-related disorder. In M. P. Adam, H. H. Ardinger, R. A. Pagon, S. E. Wallace, L. J. H. Bean, G. Mirzaa, & A. Amemiya (Eds.), GeneReviews(®). University of Washington, Seattle.
Van Splunder, J., Stilma, J. S., & Evenhuis, H. M. (2003). Visual performance in specific syndromes associated with intellectual disability. European Journal of Ophthalmology, 13(6), 566-574.
Warrier, V., Chakrabarti, B., Murphy, L., Chan, A., Craig, I., Mallya, U., Lakatošová, S., Rehnstrom, K., Peltonen, L., Wheelwright, S., Allison, C., Fisher, S. E., & Baron-Cohen, S. (2015). A pooled genome-wide association study of Asperger syndrome. PLoS One, 10(7), e0131202. https://doi.org/10.1371/journal.pone.0131202.
Wei, N. F. (1987). Genetic factors of concomitant strabismus. Zhonghua Yan Ke Za Zhi, 23(5), 282-283.
Werling, D. M., & Geschwind, D. H. (2013). Sex differences in autism spectrum disorders. Current Opinion in Neurology, 26(2), 146-153. https://doi.org/10.1097/WCO.0b013e32835ee548.
Woodhouse, J. M., Davies, N., McAvinchey, A., & Ryan, B. (2014). Ocular and visual status among children in special schools in Wales: The burden of unrecognised visual impairment. Archives of Disease in Childhood, 99(6), 500-504. https://doi.org/10.1136/archdischild-2013-304866.
Woodhouse, J. M., Pakeman, V. H., Saunders, K. J., Parker, M., Fraser, W. I., Lobo, S., & Sastry, P. (1996). Visual acuity and accommodation in infants and young children with Down's syndrome. Journal of Intellectual Disability Research, 40(Pt 1), 49-55.
Wu, C.-S., Lai, M.-S., Gau, S. S.-F., Wang, S.-C., & Tsai, H.-J. (2014). Concordance between patient self-reports and claims data on clinical diagnoses, medication use, and health system utilization in Taiwan. PLoS One, 9(12), e112257.
Ye, X. C., Pegado, V., Patel, M. S., & Wasserman, W. W. (2014). Strabismus genetics across a spectrum of eye misalignment disorders. Clinical Genetics, 86(2), 103-111. https://doi.org/10.1111/cge.12367.
Zablotsky, B., Black, L. I., Maenner, M. J., Schieve, L. A., & Blumberg, S. J. (2015). Estimated prevalence of autism and other developmental disabilities following questionnaire changes in the 2014 National Health Interview Survey. National Health Statistics Reports, 87, 1-20. https://www.cdc.gov/nchs/data/nhsr/nhsr087.pdf.
| Grant Information: |
NHRI-EX110-11008PC National Health Research Institutes; NTUH110-S4826 National Taiwan University Hospital |
| Contributed Indexing: |
Keywords: amblyopia; autism spectrum disorder; refractive errors; sex differences; strabismus |
| Entry Date(s): |
Date Created: 20230826 Latest Revision: 20231024 |
| Update Code: |
20231215 |
| DOI: |
10.1002/aur.3019 |
| PMID: |
37632715 |
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| Autor: |
Wu CS; National Center for Geriatrics and Welfare Research, National Health Research Institutes, Yunlin, Taiwan.; Department of Psychiatry, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan., Tsai TH; Department of Ophthalmology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan., Chen WL; Department of Ophthalmology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.; Advanced Ocular Surface and Corneal Nerve Regeneration Center, National Taiwan University Hospital, Taipei, Taiwan., Tsai HJ; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan., Chien YL; Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan. |
| Jazyk: |
angličtina |
| Zdroj: |
Autism research : official journal of the International Society for Autism Research [Autism Res] 2023 Oct; Vol. 16 (10), pp. 2008-2020. Date of Electronic Publication: 2023 Aug 26. |
| DOI: |
10.1002/aur.3019 |
| Abstrakt: |
Autism spectrum disorder (ASD) is associated with a high prevalence of visual dysfunction. This study aimed to investigate the rates of amblyopia, refractive errors, and strabismus, as well as their clinical correlates in ASD. This population-based matched-cohort study used data from the Taiwan National Health Insurance Research Database. A total of 3,551 youths with ASD and 35,510 non-autistic control participants matched by age and sex were included. All the participants were followed-up until they were 18 years old. The prevalence of amblyopia, refractive errors, and strabismus was compared between the ASD and control groups. Effect modifiers, including sex, ASD subgroup, and co-diagnosis of intelligence disability, were examined. Compared to the control group, youths with ASD had a significantly increased risk of amblyopia (adjusted odds ratio [aOR] = 1.75), anisometropia (aOR = 1.66), astigmatism (aOR = 1.51), hypermetropia (aOR = 2.08), exotropia (aOR = 2.86), and esotropia (aOR = 2.63), but a comparable likelihood of myopia according to age. Males with ASD had a significantly lower likelihood of exotropia, but a higher likelihood of myopia than females with ASD. The autism subgroup had a higher OR for hypermetropia, but a lower OR for myopia than the other ASD subgroups. ASD youths with intelligence disabilities demonstrated significantly higher ORs for amblyopia, hypermetropia, and all types of strabismus and lower OR for myopia than those without intelligence disabilities. In conclusion, the rates of amblyopia, refractive errors, and strabismus were higher in youths with ASD. Ocular abnormalities in youths with ASD require a comprehensive assessment and management.
(© 2023 International Society for Autism Research and Wiley Periodicals LLC.) |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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