| Autor: |
Broban A; Virology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.; Epicentre, 75017 Paris, France., Olive MM; Virology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar., Tantely ML; Medical Entomoly Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar., Dorsemans AC; Virology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar., Rakotomanana F; Epidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar., Ravalohery JP; Virology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar., Rogier C; Directorate, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.; Primum Vitare ! D'abord Prévenir !, 75015 Paris, France., Heraud JM; Virology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar., Andriamandimby SF; Virology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar. |
| Abstrakt: |
Arboviruses have been shown to circulate in Madagascar, including West Nile, dengue, and chikungunya viruses, though the extent of their circulation remains poorly documented. We estimated the seroprevalence of these three arboviruses in Madagascar and determined risk factors associated with seropositivity. Serum samples obtained from 1680 individuals surrounding the Sentinel Health Centers network in all regions of the country were analyzed using ELISA and hemagglutination inhibition assays for dengue, chikungunya, and West Nile viruses IgG antibodies, and multivariate logistic regression models were run. Overall, 6.5% [IC 95% 3.2-9.9] were seropositive for dengue virus, predominantly of Dengue serotype 1, 13.7% [IC 95% 6.5-20.9] for chikungunya virus, and 12.7% [IC 95% 9.0-16.5] for West Nile virus. There was no association with age, showing that dengue and chikungunya viruses were likely recently introduced. Eastern and Northern parts were more affected by dengue and chikungunya viruses, while West Nile virus seemed to circulate in all parts of the country. Dengue and chikungunya seropositivity were notably associated with high levels of vegetation, as well as frequent work in the forest, and West Nile seropositivity with the presence of cultivated areas, as well as standard of living. This analysis gives a new insight into arboviruses circulation and transmission patterns in Madagascar. |
