| Autor: |
Annu; Thin-Film Engineering and Materials Laboratory, School of Mechanical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.; Bio/Polymers Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India., Bhat ZI; Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India., Imtiyaz K; Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India., Rizvi MMA; Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India., Ikram S; Thin-Film Engineering and Materials Laboratory, School of Mechanical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea., Shin DK; Bio/Polymers Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India. |
| Abstrakt: |
This study aimed to synthesize chitosan/polyvinyl alcohol (CS/PVA)-based zinc oxide (ZnO) and titanium dioxide (TiO 2 ) hybrid bionanocomposites (BNCs) and observe their comparative accomplishment against the skin cancer cell line, A431, and antioxidant potential. CS was blended with PVA to form polymeric films reinforced with the immobilization of ZnO and TiO 2 nanoparticles (NPs), separately. The optimization of the BNCs was done via physicochemical studies, viz. moisture content, swelling ratio, and contact angle measurements. The free radical scavenging activity was observed for 1,1-diphenyl-2-picryl-hydrazyl, and the antibacterial assay against the Escherichia coli strain showed a higher zone of inhibition. Furthermore, the anticancer activity of the synthesized BNCs was revealed against the skin cancer cell line A431 under varying concentrations of 50, 100, 150, 200, and 300 μg/mL. The anticancer study revealed a high percent of cancerous cell inhibition (70%) in ZnO BNCs as compared to (61%) TiO 2 BNCs in a dose-dependent manner. |
